RT Journal Article SR Electronic T1 Real-World Experience with 177Lu-PSMA-617 Radioligand Therapy After Food and Drug Administration Approval JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 735 OP 739 DO 10.2967/jnumed.123.266842 VO 65 IS 5 A1 Moradi Tuchayi, Abuzar A1 Yadav, Surekha A1 Jiang, Fei A1 Kim, Sarasa T. A1 Saelee, Rachelle K. A1 Morley, Amanda A1 Juarez, Roxanna A1 Lawhn-Heath, Courtney A1 Wang, Yingbing A1 de Kouchkovsky, Ivan A1 Hope, Thomas A. YR 2024 UL http://jnm.snmjournals.org/content/65/5/735.abstract AB We report our initial real-world experience with 177Lu-PSMA-617 radioligand therapy. Methods: We performed a retrospective review of patients treated with 177Lu-PSMA-617. Pretreatment PSMA PET, laboratory findings, overall survival, a fall in prostate-specific antigen by 50% (PSA50), and toxicities were evaluated. Results: Ninety-nine patients were included. Sixty patients achieved a PSA50. Seven of 18 (39%) patients who did not meet the TheraP PSMA imaging criteria achieved a PSA50. Nineteen of 31 (61%) patients who did not meet the VISION laboratory criteria achieved a PSA50. Sixty-three patients had a delay or stoppage in therapy, which was due to a good response in 19 patients and progressive disease in 14 patients. Of 10 patients with a good response who restarted treatment, 9 subsequently achieved a PSA50 on retreatment. The most common toxicities were anemia (33%) and thrombocytopenia (21%). Conclusion: At our center, patients who did not meet the TheraP PSMA imaging criteria or the VISION laboratory criteria benefited from 177Lu-PSMA-617 radioligand therapy.