PT  - JOURNAL ARTICLE
AU  - Slart, Riemer H.J.A.
AU  - Bengel, Frank M.
AU  - Akincioglu, Cigdem
AU  - Bourque, Jamieson M.
AU  - Chen, Wengen
AU  - Dweck, Marc R.
AU  - Hacker, Marcus
AU  - Malhotra, Saurabh
AU  - Miller, Edward J.
AU  - Pelletier-Galarneau, Matthieu
AU  - Packard, René R.S.
AU  - Schindler, Thomas H.
AU  - Weinberg, Richard L.
AU  - Saraste, Antti
AU  - Slomka, Piotr J.
TI  - Total-Body PET/CT Applications in Cardiovascular Diseases: A Perspective Document of the SNMMI Cardiovascular Council
AID  - 10.2967/jnumed.123.266858
DP  - 2024 Apr 01
TA  - Journal of Nuclear Medicine
PG  - 607--616
VI  - 65
IP  - 4
4099  - http://jnm.snmjournals.org/content/65/4/607.short
4100  - http://jnm.snmjournals.org/content/65/4/607.full
SO  - J Nucl Med2024 Apr 01; 65
AB  - Digital PET/CT systems with a long axial field of view have become available and are emerging as the current state of the art. These new camera systems provide wider anatomic coverage, leading to major increases in system sensitivity. Preliminary results have demonstrated improvements in image quality and quantification, as well as substantial advantages in tracer kinetic modeling from dynamic imaging. These systems also potentially allow for low-dose examinations and major reductions in acquisition time. Thereby, they hold great promise to improve PET-based interrogation of cardiac physiology and biology. Additionally, the whole-body coverage enables simultaneous assessment of multiple organs and the large vascular structures of the body, opening new opportunities for imaging systemic mechanisms, disorders, or treatments and their interactions with the cardiovascular system as a whole. The aim of this perspective document is to debate the potential applications, challenges, opportunities, and remaining challenges of applying PET/CT with a long axial field of view to the field of cardiovascular disease.