PT - JOURNAL ARTICLE AU - Dubash, Suraiya AU - Barwick, Tara D. AU - Kozlowski, Kasia AU - Rockall, Andrea G. AU - Khan, Sairah AU - Khan, Sameer AU - Yusuf, Siraj AU - Lamarca, Angela AU - Valle, Juan W. AU - Hubner, Richard A. AU - McNamara, Mairéad G. AU - Frilling, Andrea AU - Tan, Tricia AU - Wernig, Florian AU - Todd, Jeannie AU - Meeran, Karim AU - Pratap, Bhavesh AU - Azeem, Saleem AU - Huiban, Michael AU - Keat, Nicholas AU - Lozano-Kuehne, Jingky P. AU - Aboagye, Eric O. AU - Sharma, Rohini TI - Somatostatin Receptor Imaging with [<sup>18</sup>F]FET-βAG-TOCA PET/CT and [<sup>68</sup>Ga]Ga-DOTA-Peptide PET/CT in Patients with Neuroendocrine Tumors: A Prospective, Phase 2 Comparative Study AID - 10.2967/jnumed.123.266601 DP - 2024 Mar 01 TA - Journal of Nuclear Medicine PG - 416--422 VI - 65 IP - 3 4099 - http://jnm.snmjournals.org/content/65/3/416.short 4100 - http://jnm.snmjournals.org/content/65/3/416.full SO - J Nucl Med2024 Mar 01; 65 AB - There is a clinical need for 18F-labeled somatostatin analogs for the imaging of neuroendocrine tumors (NET), given the limitations of using [68Ga]Ga-DOTA-peptides, particularly with regard to widespread accessibility. We have shown that [18F]fluoroethyl-triazole-[Tyr3]-octreotate ([18F]FET-βAG-TOCA) has favorable dosimetry and biodistribution. As a step toward clinical implementation, we conducted a prospective, noninferiority study of [18F]FET-βAG-TOCA PET/CT compared with [68Ga]Ga-DOTA- peptide PET/CT in patients with NET. Methods: Forty-five patients with histologically confirmed NET, grades 1 and 2, underwent PET/CT imaging with both [18F]FET-βAG-TOCA and [68Ga]Ga-peptide performed within a 6-mo window (median, 77 d; range, 6–180 d). Whole-body PET/CT was conducted 50 min after injection of 165 MBq of [18F]FET-βAG-TOCA. Tracer uptake was evaluated by comparing SUVmax and tumor-to-background ratios at both lesion and regional levels by 2 unblinded, experienced readers. A randomized, blinded reading of both scans was also then undertaken by 3 experienced readers, and consensus was assessed at a regional level. The ability of both tracers to visualize liver metastases was also assessed. Results: A total of 285 lesions were detected on both imaging modalities. An additional 13 tumor deposits were seen in 8 patients on [18F]FET-βAG-TOCA PET/CT, and [68Ga]Ga-DOTA-peptide PET/CT detected an additional 7 lesions in 5 patients. Excellent correlation in SUVmax was observed between both tracers (r = 0.91; P &lt; 0.001). No difference was observed between median SUVmax across regions, except in the liver, where the median tumor-to-background ratio of [18F]FET-βAG-TOCA was significantly lower than that of [68Ga]Ga-DOTA-peptide (2.5 ± 1.9 vs. 3.5 ± 2.3; P &lt; 0.001). Conclusion: [18F]FET-βAG-TOCA was not inferior to [68Ga]Ga-DOTA-peptide in visualizing NET and may be considered in routine clinical practice given the longer half-life and availability of the cyclotron-produced fluorine radioisotope.