RT Journal Article
SR Electronic
T1 Total-Body PET/CT Applications in Cardiovascular Diseases: A Perspective Document of the SNMMI Cardiovascular Council
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.123.266858
DO 10.2967/jnumed.123.266858
A1 Slart, Riemer H.J.A.
A1 Bengel, Frank M.
A1 Akincioglu, Cigdem
A1 Bourque, Jamieson M.
A1 Chen, Wengen
A1 Dweck, Marc R.
A1 Hacker, Marcus
A1 Malhotra, Saurabh
A1 Miller, Edward J.
A1 Pelletier-Galarneau, Matthieu
A1 Packard, René R.S.
A1 Schindler, Thomas H.
A1 Weinberg, Richard L.
A1 Saraste, Antti
A1 Slomka, Piotr J.
YR 2024
UL http://jnm.snmjournals.org/content/early/2024/02/22/jnumed.123.266858.abstract
AB Digital PET/CT systems with a long axial field of view have become available and are emerging as the current state of the art. These new camera systems provide wider anatomic coverage, leading to major increases in system sensitivity. Preliminary results have demonstrated improvements in image quality and quantification, as well as substantial advantages in tracer kinetic modeling from dynamic imaging. These systems also potentially allow for low-dose examinations and major reductions in acquisition time. Thereby, they hold great promise to improve PET-based interrogation of cardiac physiology and biology. Additionally, the whole-body coverage enables simultaneous assessment of multiple organs and the large vascular structures of the body, opening new opportunities for imaging systemic mechanisms, disorders, or treatments and their interactions with the cardiovascular system as a whole. The aim of this perspective document is to debate the potential applications, challenges, opportunities, and remaining challenges of applying PET/CT with a long axial field of view to the field of cardiovascular disease.