RT Journal Article
SR Electronic
T1 Quantitative Perfusion Imaging with Total-Body PET
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 11S
OP 19S
DO 10.2967/jnumed.122.264870
VO 64
IS Supplement 2
A1 Knuuti, Juhani
A1 Tuisku, Jouni
A1 Kärpijoki, Henri
A1 Iida, Hidehiro
A1 Maaniitty, Teemu
A1 Latva-Rasku, Aino
A1 Oikonen, Vesa
A1 Nesterov, Sergey V.
A1 Teuho, Jarmo
A1 Jaakkola, Maria K.
A1 Klén, Riku
A1 Louhi, Heli
A1 Saunavaara, Virva
A1 Nuutila, Pirjo
A1 Saraste, Antti
A1 Rinne, Juha
A1 Nummenmaa, Lauri
YR 2023
UL http://jnm.snmjournals.org/content/64/Supplement_2/11S.abstract
AB Recently, PET systems with a long axial field of view have become the current state of the art. Total-body PET scanners enable unique possibilities for scientific research and clinical diagnostics, but this new technology also raises numerous challenges. A key advantage of total-body imaging is that having all the organs in the field of view allows studying biologic interaction of all organs simultaneously. One of the new, promising imaging techniques is total-body quantitative perfusion imaging. Currently, 15O-labeled water provides a feasible option for quantitation of tissue perfusion at the total-body level. This review summarizes the status of the methodology and the analysis and provides examples of preliminary findings on applications of quantitative parametric perfusion images for research and clinical work. We also describe the opportunities and challenges arising from moving from single-organ studies to modeling of a multisystem approach with total-body PET, and we discuss future directions for total-body imaging.