RT Journal Article
SR Electronic
T1 The Diagnostic Value of the Sentinel Node Procedure to Detect Occult Lymph Node Metastases in PSMA PET/CT Node–Negative Prostate Cancer Patients
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1563
OP 1566
DO 10.2967/jnumed.123.265556
VO 64
IS 10
A1 Duin, Jan J.
A1 de Barros, Hilda A.
A1 Donswijk, Maarten L.
A1 Schaake, Eva E.
A1 van der Sluis, Tim M.
A1 Wit, Esther M.K.
A1 van Leeuwen, Fijs W.B.
A1 van Leeuwen, Pim J.
A1 van der Poel, Henk G.
YR 2023
UL http://jnm.snmjournals.org/content/64/10/1563.abstract
AB Our objective was to assess the diagnostic value of the sentinel node (SN) procedure for lymph node staging in primary intermediate- and high-risk prostate cancer patients with node-negative results on prostate-specific membrane antigen PET/CT (miN0). Methods: From 2016 to 2022, 154 patients with primary, miN0 PCa were retrospectively included. All patients had a Briganti nomogram–assessed nodal risk of more than 5% and underwent a robot-assisted SN procedure for nodal staging. The prevalence of nodal metastases at histopathology and the occurrence of surgical complications according to the Clavien–Dindo classification were evaluated. Results: The SN procedure yielded 84 (14%) tumor-positive lymph nodes with a median metastasis size of 3 mm (interquartile range, 1–4 mm). In total, 55 patients (36%) were reclassified as pN1. A complication of Clavien–Dindo grade 3 or higher occured in 1 patient (0.6%). Conclusion: The SN procedure classified 36% of patients with miN0 prostate cancer with an elevated risk of nodal metastases as pN1.