PT  - JOURNAL ARTICLE
AU  - Duin, Jan J.
AU  - de Barros, Hilda A.
AU  - Donswijk, Maarten L.
AU  - Schaake, Eva E.
AU  - van der Sluis, Tim M.
AU  - Wit, Esther M.K.
AU  - van Leeuwen, Fijs W.B.
AU  - van Leeuwen, Pim J.
AU  - van der Poel, Henk G.
TI  - The Diagnostic Value of the Sentinel Node Procedure to Detect Occult Lymph Node Metastases in PSMA PET/CT Node–Negative Prostate Cancer Patients
AID  - 10.2967/jnumed.123.265556
DP  - 2023 Oct 01
TA  - Journal of Nuclear Medicine
PG  - 1563--1566
VI  - 64
IP  - 10
4099  - http://jnm.snmjournals.org/content/64/10/1563.short
4100  - http://jnm.snmjournals.org/content/64/10/1563.full
SO  - J Nucl Med2023 Oct 01; 64
AB  - Our objective was to assess the diagnostic value of the sentinel node (SN) procedure for lymph node staging in primary intermediate- and high-risk prostate cancer patients with node-negative results on prostate-specific membrane antigen PET/CT (miN0). Methods: From 2016 to 2022, 154 patients with primary, miN0 PCa were retrospectively included. All patients had a Briganti nomogram–assessed nodal risk of more than 5% and underwent a robot-assisted SN procedure for nodal staging. The prevalence of nodal metastases at histopathology and the occurrence of surgical complications according to the Clavien–Dindo classification were evaluated. Results: The SN procedure yielded 84 (14%) tumor-positive lymph nodes with a median metastasis size of 3 mm (interquartile range, 1–4 mm). In total, 55 patients (36%) were reclassified as pN1. A complication of Clavien–Dindo grade 3 or higher occured in 1 patient (0.6%). Conclusion: The SN procedure classified 36% of patients with miN0 prostate cancer with an elevated risk of nodal metastases as pN1.