PT - JOURNAL ARTICLE AU - Song, Tianbin AU - Zang, Zhenxiang AU - Li, jiping AU - nie, binbin AU - Mei, shanshan AU - Shan, Baoci AU - zhang, chun AU - Zhang, yuqing AU - Lu, Jie TI - <strong>Distinct Functional Connectivity of the Cortical-Basal Ganglia-Thalamus Circuits Is Associated Differently with Glucose Metabolism Between Patients with Parkinson’s Disease and Healthy Population: A 18FDG PET-MRI Study</strong> DP - 2023 Jun 01 TA - Journal of Nuclear Medicine PG - P924--P924 VI - 64 IP - supplement 1 4099 - http://jnm.snmjournals.org/content/64/supplement_1/P924.short 4100 - http://jnm.snmjournals.org/content/64/supplement_1/P924.full SO - J Nucl Med2023 Jun 01; 64 AB - P924 Introduction: Parkinson's disease (PD) had main clinical features,such as motor symptoms, which have a causal factor in dopamine depletion in the basal ganglia circuit . Over the last 30 years, studies have been made in understanding the network physiology of cortical-basal ganglia (BG)-thalamic circuits in health and disease. Granger Causality applied to functional Magnetic Resonance Imaging (fMRI) had been studied cortico-thalamo-striato-cortical connections in PD, which confirming the weaker interaction between the caudate and the motor cortex.The aim of this study is to identify associations between functional connectivity and glucose metabolism in cortical-cortical network and cortical-basal ganglia-thalamus network in PD patients by acquiring simultaneous PET/fMRI data, which helps us to better understand the pathophysiological mechanism of PD.Methods: Forty PD patients and 30 healthy controls were collected at Xuanwu Hospital, Capital Medical University in the year of 2019 and 2020. All subjects underwent hybrid PET/MR examination (averaged duration between tracer injection and scan was one hour) by using hybrid PET/MR system (uPMR790, UIH, Shanghai, China), which features simultaneous PET imaging with 3.0T MR with a 24-channel head/neck coil. All patients were fasted for at least 6 hours before PET/MR examination. PD patients were instructed to not using Levodopa 12 hours prior to the scan.The injected dose of 18F-FDG of subject was 3.7 MBq/kg. PET acquisition time of one bed position was lasted 10 min covering from the top of the skull. Resting-state fMRI was performed using an echo-planar imaging (EPI) sequence with the following parameters: TR = 2000 ms, TE = 30 ms, 34 axial slices per volume, voxel size = 3&amp;times;3 x 3 mm, 1 mm slice gap(230 whole-brain scans).Results: Hyper connectivity were found in a cortical-cortical and cortical-BG-THA network in PDThe NBS identified two networks that showed significant increased functional connectivity in the PD population. A cortical-cortical network consists of motor, premotor and prefrontal regions (PFWE = 0.032) and a cortical-basal ganglia-thalamus network consists of brain regions distributed in the sensorimotor, putamen, pallidum and thalamus (PFWE &lt; 0.001).Increased FDG uptake in the sensorimotor regions, putamen and thalamus We found that the FDG uptake were significantly increased in 6 out of 25 nodes within the identified networks (Figure1). Four of them are in the sensorimotor cortex (left precentral/postcentral gyrus, bilateral paracentral lobules) and one located at the dorsal putamen and one in the thalamus. Further, we found significant positive correlation between the FDG uptake in the left postcentral gyrus and the UPDRS III and H-Ystage ( P = 0.004; P = 0.046).FDG uptake in the putamen and thalamus are associated differently with the cortical-cortical functional connectivityFor the HC group, post-hoc analyses further revealed significant positive association between the cortical-cortical connectivity and FDG uptake in the thalamus (r = 0.42, P = 0.035) and towards to significant association in the putamen (r= 0.38, P = 0.06). Such associations were far from significant in the PD population (P values &gt; 0.6).No significant interaction effects were found between the FDG uptake in the subcortical nodes (thalamus and putamen) and the connectivity of cortical-basal ganglia-thalamus network (P values &gt; 0.21).Conclusions: The present findings suggest that the link between functional connectivity and glucose metabolism in both cortical-cortical and cortical-basal ganglia-thalamus networks in PD patients by acquiring simultaneous PET/fMRI data combines 18F-FDG-PET and resting-state functional MRI, which is highlighting the capability of multimodal imaging protocols as biomarkers, which may be suitable for quantification of PD progression. The identification of defective nodes of a network may provide a therapeutic target for future interventional trials.