RT Journal Article
SR Electronic
T1 <strong>[18F]mFBG Long Axial Field Of View (LAFOV) PET/CT without sedation or general anaesthesia compared to [123I]mIBG scintigraphy with single-photon emission computed tomography-CT (SPECT/CT) for imaging of children with neuroblastoma.</strong>
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP P1313
OP P1313
VO 64
IS supplement 1
A1 Borgwardt, Lise
A1 brok, jesper
A1 Andersen, Kim Francis
A1 Madsen, Jacob
A1 Gillings, Nicholas
A1 Fosbøl, Marie
A1 denholt, charlotte
A1 Enevoldsen, lotte
A1 Oturai, Peter
A1 Johannesen, Helle
A1 Czyzewska, Dorota
A1 Højgaard, Liselotte
A1 Andersen, Flemming
A1 Fischer, Barbara
YR 2023
UL http://jnm.snmjournals.org/content/64/supplement_1/P1313.abstract
AB P1313 Introduction: Meta-[18F]fluorobenzylguanidine ([18F]mFBG) is a new positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging of tumours expressing the norepinephrine transporter. These initial results investigates the value of [18F]mFBG Long Axial Field Of View (LAFOV) PET/CT compared to 'standard' [123I]mIBG scintigraphy with single-photon emission computed tomography-CT (SPECT/CT) for imaging in neuroblastoma.Methods: Prospective, single-center study, that recruited children with neuroblastoma, referred for meta-[123I]iodobenzylguanidine ([123I]mIBG) whole body planar scintigraphy with SPECT/CT of the thorax and abdomen. Within 1 week of [123I]mIBG scintigraphy, [18F]mFBG LAFOV PET/CT (Siemens Vision Quadra PET/CT) were performed at 1 h p.i. of [18F]mFBG (1.5-3 MBq/kg) without sedation or general anaesthesia (GA). The PET acquisition time was 10 min., if possible for the child, with only 2 min. of reconstruction required (being the minimum required scanning time in order to provide a clinically useful image) and by scanning 10 min. the periods without motion artefacts could be reconstructed. Tumour localisation and extension on paired scan were compared.Results: 16 paired [123I]mIBG and [18F]mFBG scans were performed in 8 patients (median age 3.25 years (0.25-8.08 y), n = 2 stage L2(low risk), n=1 stage L2(intermediate risk), n=1 stage L2(high risk/relaps), n=2 stage M (high risk), n=1 stage M (high risk/relaps), n=1 stage MS. Mean scan time for [18F]mFBG PET-CT (7.7 min, SD 2.6) was significantly shorter than for [123I]mIBG scanning (72.5 min, SD 16.3), p &lt; 0.01. None of the children had sedation or GA during the PET scanning procedure, whereas 81% had GA during the [123I]mIBG scintigraphy with SPECT/CT. Compared to [123I]mIBG scintigraphy, [18F]mFBG PET-CT detected a higher, equal, and lower number of avid lesions in 75%, 25%, and 0% of scan pairs, respectively. Especially, intraspinal-, retroperitoneal lymph node-, and bone marrow involvement is diagnosed with much higher accuracy in [18F]mFBG LAFOV PET/CT compared to [123I]mIBG scintigraphy with SPECT/CT.Conclusions: Preliminary results demonstrate that more neuroblastoma localisations were detected on [18F]mFBG LAFOV PET/CT compared to [123I]mIBG scintigraphy with SPECT/CT. The clinical benefit of [18F]mFBG LAFOV PET/CT is a 1 day protocol, much shorter scan time and avoidance of GA/sedation in most patients. [18F]mFBG LAFOV PET/CT shows promise for future staging and response assessment in neuroblastoma in children.