RT Journal Article SR Electronic T1 Characterization of four major psychiatric disorders based on AMPA receptor distributions measured with [11C]K-2: a novel PET tracer study JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP P237 OP P237 VO 64 IS supplement 1 A1 Hatano, Mai A1 Nakajima, Waki A1 Uchida, Hiroyuki A1 Miyazaki, Tomoyuki A1 Arisawa, Tetsu A1 Takada, Yuuki A1 Tsugawa, Sakiko A1 Sano, Akane A1 Nakano, Kotaro A1 Eiro, Tsuyoshi A1 Abe, Hiroki A1 Suda, Akira A1 Asami, Takeshi A1 Hishimoto, Akitoyo A1 Tani, Hideaki A1 Nagai, Nobuhiro A1 Koizumi, Teruki A1 Nakajima, Shinichiro A1 Kurokawa, Shunya A1 Ohtani, Yohei A1 Takahashi, Kie A1 Kikuchi, Yuhei A1 Yatomi, Taisuke A1 Honda, Shiori A1 Jinzaki, Masahiro A1 Hirano, Yoji A1 Mitoma, Ryo A1 Tamura, Shunsukta A1 Baba, Shingo A1 Togao, Osamu A1 Kosaka, Hirotaka A1 Okazawa, Hidehiko A1 Kimura, Yuichi A1 Mimura, Masaru A1 Takahashi, Takuya YR 2023 UL http://jnm.snmjournals.org/content/64/supplement_1/P237.abstract AB P237 Introduction: Synaptic phenotypes in living patients with psychiatric disorders are poorly characterized. Excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) is a fundamental component for neurotransmission. We recently developed a positron emission tomography (PET) tracer for AMPAR, [11C]K-2, the first technology to visualize AMPARs in living human brain.Methods: One hundred forty-nine patients with psychiatric disorders (schizophrenia, n=42; bipolar disorder, n=37; depression, n=35; and autism spectrum disorder, n=35) and 70 healthy participants underwent a PET scan with [11C]K-2 for measurement of AMPAR density. Brain regions with correlation between AMPAR density and symptomatology scores of each disease and those that showed differences in AMPAR density between patients and healthy participants were identified by using a voxel-wise analysis.Results: Specific brain regions that showed correlation between AMPAR density and symptomatology scores were detected in each of four disorders. We also found brain areas with significant differences in AMPAR density between patients with each psychiatric disorder and healthy participants. Some of these areas were observed across diseases, indicating that these are commonly affected areas throughout psychiatric disorders.Conclusions: Schizophrenia, bipolar disorder, depression, and autism spectrum disorder are uniquely characterized by AMPAR distribution patterns. Moreover, the presence of the commonly affected regions in comparison to healthy controls suggests that these disorders may share the biological characteristic in terms of AMPAR. Our approach to psychiatric disorders using [11C]K-2 can elucidate the biological mechanisms across diseases and pave the way to develop novel diagnostics and therapeutics based on the synapse physiology.