RT Journal Article SR Electronic T1 Evaluation of [68Ga]-DOTATOC PET/MRI in Patients with Meningioma of the Subcranial and Intraorbital Space JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1185 OP 1190 DO 10.2967/jnumed.123.265424 VO 64 IS 8 A1 Milosevic, Aleksandar A1 Styczen, Hanna A1 Grueneisen, Johannes A1 Li, Yan A1 Weber, Manuel A1 Fendler, Wolfgang P. A1 Kirchner, Julian A1 Damman, Philipp A1 Wrede, Karsten A1 Lazaridis, Lazaros A1 Glas, Martin A1 Guberina, Maja A1 Eckstein, Anja A1 Blau, Tobias A1 Herrmann, Ken A1 Umutlu, Lale A1 Forsting, Michael A1 Deuschl, Cornelius A1 Schaarschmidt, Benedikt YR 2023 UL http://jnm.snmjournals.org/content/64/8/1185.abstract AB Meningiomas are known to express somatostatin receptor (SSTR) type 2 to a high degree. Therefore, radiolabeled somatostatin analogs, such as DOTATOC, have been introduced for PET imaging of meningiomas. However, the benefit of hybrid SSTR PET/MRI is still debated. Here, we report our experience with [68Ga]-DOTATOC PET/MRI. Methods: PET/MRI was performed in 60 patients with suspected or diagnosed meningiomas of the skull plane and eye socket. Acquired datasets were reported by 2 independent readers regarding local tumor extent and signal characteristics. Histopathologic results and follow-up imaging served as the reference standard. SUVs of target lesions were analyzed according to the corresponding maximal tracer uptake. The diagnostic accuracy of PET/MRI and conventional MRI was determined independently and compared with the reference standard. Results: In total, 60 target lesions were identified, with 54 considered to be meningiomas according to the reference standard. Sensitivity and specificity of PET/MRI versus MRI alone were 95% versus 96% and 75% versus 66%, respectively. The McNemar test was not able to distinguish any differences between PET/MRI and the reference standard or MRI and the reference standard. No differences were found between the 2 modalities with respect to local infiltration. Conclusion: SSTR PET/MRI and MRI yielded similar accuracy for the detection of meningiomas of the skull base and intraorbital space. Here, sequential low-dose SSTR PET/CT might be helpful for the planning of radioligand therapy or radiotherapy.