PT - JOURNAL ARTICLE AU - Chen, Ruohua AU - Yang, Xinlan AU - Ng, Yee Ling AU - Yu, Xiaofeng AU - Huo, Yanmiao AU - Xiao, Xiuying AU - Zhang, Chenpeng AU - Chen, Yumei AU - Zheng, Chaojie AU - Li, Lianghua AU - Huang, Gang AU - Zhou, Yun AU - Liu, Jianjun TI - First Total-Body Kinetic Modeling and Parametric Imaging of Dynamic <sup>68</sup>Ga-FAPI-04 PET in Pancreatic and Gastric Cancer AID - 10.2967/jnumed.122.264988 DP - 2023 Jun 01 TA - Journal of Nuclear Medicine PG - 960--967 VI - 64 IP - 6 4099 - http://jnm.snmjournals.org/content/64/6/960.short 4100 - http://jnm.snmjournals.org/content/64/6/960.full SO - J Nucl Med2023 Jun 01; 64 AB - Fibroblast activation protein inhibitor (FAPI) is an ideal diagnostic and therapeutic target in malignant tumors. However, the knowledge of kinetic modeling and parametric imaging of 68Ga-FAPI is limited. Purpose: The purpose of this study was to explore the pharmacokinetics of 68Ga-FAPI-04 PET/CT in pancreatic cancer and gastric cancer and to conduct parametric imaging of dynamic total-body data compared with SUV imaging. Methods: Dynamic total-body 68Ga-FAPI-04 PET/CT was performed on 13 patients. The lesion time–activity curves were fitted by 3-compartment models and multigraphical models. The kinetics parameters derived from the 2-tissue reversible compartment model (2T4K) and multigraphical models were analyzed. Parametric imaging was generated using the 2T4K and Logan models, and their performances were evaluated compared with SUV images. Results: 2T4K had the lowest Akaike information criterion value, and its fitting curves matched excellently with the origin time–activity curves. Visual assessment revealed that the (2T4K) images and (Logan with spatial constraint [SC]) images both showed less image noise and higher lesion conspicuity compared with SUV images. Objective image quality assessment demonstrated that parametric (2T4K) images and parametric (Logan with SC) images had a 5.0-fold and 5.0-fold higher average signal-to-noise ratio and 3.6-fold and 4.1-fold higher average contrast-to-noise ratio compared with conventional SUV images, respectively. In addition, no significant differences in signal-to-noise ratio and contrast-to-noise of pathologic lesions were observed between parametric (2T4K) images and parametric (Logan with SC) images (all P &gt; 0.05). Conclusions: The 2T4K model was the preferred compartment model. Total-body parametric imaging of 68Ga-FAPI-04 PET yielded superior quantification beyond SUV with enhanced lesion contrast, which may serve as a promising imaging method to make an early diagnosis, to better reflect tumor characterization, or to allow evaluation of treatment response. (2T4K) images are comparable in image quality and consistent to (Logan with SC) images in lesions conspicuity; however, (Logan with SC) images presented an appealing alternative to (2T4K) images because of their simplicity.