PT - JOURNAL ARTICLE AU - Norbert Galldiks AU - Philipp Lohmann AU - Gereon R. Fink AU - Karl-Josef Langen TI - Amino Acid PET in Neurooncology AID - 10.2967/jnumed.122.264859 DP - 2023 May 01 TA - Journal of Nuclear Medicine PG - 693--700 VI - 64 IP - 5 4099 - http://jnm.snmjournals.org/content/64/5/693.short 4100 - http://jnm.snmjournals.org/content/64/5/693.full SO - J Nucl Med2023 May 01; 64 AB - For decades, several amino acid PET tracers have been used to optimize diagnostics in patients with brain tumors. In clinical routine, the most important clinical indications for amino acid PET in brain tumor patients are differentiation of neoplasm from nonneoplastic etiologies, delineation of tumor extent for further diagnostic and treatment planning (i.e., diagnostic biopsy, resection, or radiotherapy), differentiation of treatment-related changes such as pseudoprogression or radiation necrosis after radiation or chemoradiation from tumor progression at follow-up, and assessment of response to anticancer therapy, including prediction of patient outcome. This continuing education article addresses the diagnostic value of amino acid PET for patients with either glioblastoma or metastatic brain cancer.