RT Journal Article
SR Electronic
T1 Functional imaging of chemo-brain: usefulness of Nuclear Medicine in the fog coming after cancer
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.121.263294
DO 10.2967/jnumed.121.263294
A1 Agostino Chiaravalloti
A1 Luca Filippi
A1 Marco Pagani
A1 Orazio Schillaci
YR 2023
UL http://jnm.snmjournals.org/content/early/2023/02/02/jnumed.121.263294.abstract
AB The impact of chemotherapy on brain functionality has been widely investigated from a clinical perspective and there is a consensus on a significant impairment of multiple cognitive domains affecting cancer patients after treatment. Nuclear medicine offers a variety of biomarkers for the evaluation of possible effects of chemotherapy on the brain and for depicting brain changes after chemotherapy treatment. This review aims to summarize the most relevant findings on brain imaging in patients treated with chemotherapy for the most common oncological diseases. The literature published to date offers exciting results with several radiolabeled compounds, from the more common imaging of glucose metabolism to neuroinflammation. In this review, a general overview of the literature concerning clinical features and the physiopathological basis of chemotherapy-related cognitive impairment is reported as well.