RT Journal Article SR Electronic T1 Artificial Intelligence in Nuclear Medicine: Opportunities, Challenges, and Responsibilities Toward a Trustworthy Ecosystem JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 188 OP 196 DO 10.2967/jnumed.121.263703 VO 64 IS 2 A1 Babak Saboury A1 Tyler Bradshaw A1 Ronald Boellaard A1 Irène Buvat A1 Joyita Dutta A1 Mathieu Hatt A1 Abhinav K. Jha A1 Quanzheng Li A1 Chi Liu A1 Helena McMeekin A1 Michael A. Morris A1 Peter J.H. Scott A1 Eliot Siegel A1 John J. Sunderland A1 Neeta Pandit-Taskar A1 Richard L. Wahl A1 Sven Zuehlsdorff A1 Arman Rahmim YR 2023 UL http://jnm.snmjournals.org/content/64/2/188.abstract AB Trustworthiness is a core tenet of medicine. The patient–physician relationship is evolving from a dyad to a broader ecosystem of health care. With the emergence of artificial intelligence (AI) in medicine, the elements of trust must be revisited. We envision a road map for the establishment of trustworthy AI ecosystems in nuclear medicine. In this report, AI is contextualized in the history of technologic revolutions. Opportunities for AI applications in nuclear medicine related to diagnosis, therapy, and workflow efficiency, as well as emerging challenges and critical responsibilities, are discussed. Establishing and maintaining leadership in AI require a concerted effort to promote the rational and safe deployment of this innovative technology by engaging patients, nuclear medicine physicians, scientists, technologists, and referring providers, among other stakeholders, while protecting our patients and society. This strategic plan was prepared by the AI task force of the Society of Nuclear Medicine and Molecular Imaging.