TY - JOUR T1 - Distinction of Lymphoma from Sarcoidosis on <sup>18</sup>F-FDG PET/CT: Evaluation of Radiomics-Feature–Guided Machine Learning Versus Human Reader Performance JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1933 LP - 1940 DO - 10.2967/jnumed.121.263598 VL - 63 IS - 12 AU - Pierre Lovinfosse AU - Marta Ferreira AU - Nadia Withofs AU - Alexandre Jadoul AU - Céline Derwael AU - Anne-Noelle Frix AU - Julien Guiot AU - Claire Bernard AU - Anh Nguyet Diep AU - Anne-Françoise Donneau AU - Marie Lejeune AU - Christophe Bonnet AU - Wim Vos AU - Patrick E. Meyer AU - Roland Hustinx Y1 - 2022/12/01 UR - http://jnm.snmjournals.org/content/63/12/1933.abstract N2 - Sarcoidosis and lymphoma often share common features on 18F-FDG PET/CT, such as intense hypermetabolic lesions in lymph nodes and multiple organs. We aimed at developing and validating radiomics signatures to differentiate sarcoidosis from Hodgkin lymphoma (HL) and diffuse large B-cell lymphoma (DLBCL). Methods: We retrospectively collected 420 patients (169 sarcoidosis, 140 HL, and 111 DLBCL) who underwent pretreatment 18F-FDG PET/CT at the University Hospital of Liege. The studies were randomly distributed to 4 physicians, who gave their diagnostic suggestion among the 3 diseases. The individual and pooled performance of the physicians was then calculated. Interobserver variability was evaluated using a sample of 34 studies interpreted by all physicians. Volumes of interest were delineated over the lesions and the liver using MIM software, and 215 radiomics features were extracted using the RadiomiX Toolbox. Models were developed combining clinical data (age, sex, and weight) and radiomics (original and tumor-to-liver TLR radiomics), with 7 different feature selection approaches and 4 different machine-learning (ML) classifiers, to differentiate sarcoidosis and lymphomas on both lesion-based and patient-based approaches. Results: For identifying lymphoma versus sarcoidosis, physicians’ pooled sensitivity, specificity, area under the receiver-operating-characteristic curve (AUC), and accuracy were 0.99 (95% CI, 0.97–1.00), 0.75 (95% CI, 0.68–0.81), 0.87 (95% CI, 0.84–0.90), and 89.3%, respectively, whereas for identifying HL in the tumor population, it was 0.58 (95% CI, 0.49–0.66), 0.82 (95% CI, 0.74–0.89), 0.70 (95% CI, 0.64–0.75) and 68.5%, respectively. Moderate agreement was found among observers for the diagnosis of lymphoma versus sarcoidosis and HL versus DLBCL, with Fleiss κ-values of 0.66 (95% CI, 0.45–0.87) and 0.69 (95% CI, 0.45–0.93), respectively. The best ML models for identifying lymphoma versus sarcoidosis showed an AUC of 0.94 (95% CI, 0.93–0.95) and 0.85 (95% CI, 0.82–0.88) in lesion- and patient-based approaches, respectively, using TLR radiomics (plus age for the second). To differentiate HL from DLBCL, we obtained an AUC of 0.95 (95% CI, 0.93–0.96) in the lesion-based approach using TLR radiomics and 0.86 (95% CI, 0.80–0.91) in the patient-based approach using original radiomics and age. Conclusion: Characterization of sarcoidosis and lymphoma lesions is feasible using ML and radiomics, with very good to excellent performance, equivalent to or better than that of physicians, who showed significant interobserver variability in their assessment. ER -