RT Journal Article
SR Electronic
T1 Dual-Tracer PET/CT Protocol with [<sup>18</sup>F]-FDG and [<sup>68</sup>Ga]Ga-FAPI-46 for Cancer Imaging: A Proof of Concept
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1683
OP 1686
DO 10.2967/jnumed.122.263835
VO 63
IS 11
A1 Roth, Katrin S.
A1 Voltin, Conrad-Amadeus
A1 van Heek, Lutz
A1 Wegen, Simone
A1 Schomäcker, Klaus
A1 Fischer, Thomas
A1 Marnitz, Simone
A1 Drzezga, Alexander
A1 Kobe, Carsten
YR 2022
UL http://jnm.snmjournals.org/content/63/11/1683.abstract
AB Imaging studies with PET tracers acting as fibroblast activation protein inhibitors (FAPIs) show promising results that could usefully complement [18F]-FDG in cancer imaging. Methods: All patients received [18F]-FDG PET/CT and dual-tracer PET/CT after an additional injection of [68Ga]Ga-FAPI-46 after the [18F]-FDG PET/CT. Two readers visually compared detection rate and analyzed target-to-background ratios for tumor and metastatic tissue in single- and dual-tracer PET/CT. Results: Detection rate in dual-tracer PET/CT was visually as good as that in single-tracer PET/CT in 4 patients and superior in 2 patients, whereas target-to-background ratios were significantly higher in dual-tracer PET/CT. Conclusion: Dual-tracer [18F]-FDG/[68Ga]Ga-FAPI-46 PET/CT within a single session is feasible and has potential. The dual-tracer approach may have superior sensitivity to [18F]-FDG PET/CT alone without compromising individual assessment of either scan.