RT Journal Article
SR Electronic
T1 Antibody Engineering for Nuclear Imaging and Radioimmunotherapy
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1316
OP 1322
DO 10.2967/jnumed.122.263861
VO 63
IS 9
A1 Cindy Rodriguez
A1 Samantha Delaney
A1 Samantha M. Sarrett
A1 Outi M. Keinänen
A1 Brian M. Zeglis
YR 2022
UL http://jnm.snmjournals.org/content/63/9/1316.abstract
AB Radiolabeled antibodies have become indispensable tools in nuclear medicine. However, the natural roles of antibodies within the immune system mean that they have several intrinsic limitations as a platform for radiopharmaceuticals. In recent years, the field has increasingly turned to antibody engineering to circumvent these issues while retaining the manifold benefits of the immunoglobulin framework. In this “Focus on Molecular Imaging” review, we cover recent advances in the application of antibody engineering to immunoPET, immunoSPECT, and radioimmunotherapy. Specifically, we address how antibody engineering has been used to improve radioimmunoconjugates on four fronts: optimizing pharmacokinetics, facilitating site-specific bioconjugation, modulating Fc interactions, and creating bispecific constructs.