PT  - JOURNAL ARTICLE
AU  - Fukami, Mitsuha
AU  - Matsutomo, Norikazu
AU  - Takeyuki, Hashimoto
AU  - Yamamoto, Tomoaki
AU  - Sasaki, Masayuki
TI  - <strong>The application of compressed sensing reconstruction for myocardial perfusion image shortens the acquisition time: a simulation study</strong>
DP  - 2022 Aug 01
TA  - Journal of Nuclear Medicine
PG  - 4097--4097
VI  - 63
IP  - supplement 2
4099  - http://jnm.snmjournals.org/content/63/supplement_2/4097.short
4100  - http://jnm.snmjournals.org/content/63/supplement_2/4097.full
SO  - J Nucl Med2022 Aug 01; 63
AB  - 4097 Introduction: The compressed sensing (CS) theory has been applied to medical image reconstruction to improve the quality of sparse single-photon emission computed tomography (SPECT) images. It enables a dynamic study on the calculation of myocardial flow reserve with a general gamma camera if CS reconstruction is applied for time reduction in myocardial perfusion images (MPIs). Thus, this initial study aimed to evaluate the performance of CS-iterative reconstruction (IR) compared to filtered back-projection (FBP) and maximum likelihood expectation maximization (ML-EM) toward the reduction of acquisition time of MPI.Methods: Digital phantom that mimicked the left ventricular myocardium was made for simulation. The projection data were simulated with 120 projection (360°) and 60 projection (180°) by SIMIND Monte Carlo programs. The SPECT image was reconstructed by FBP, ML-EM, and CS-IR. The coefficient of variation (CV) for uniformity of myocardial accumulation, full width at half maximum (FWHM) of the septal wall, and contrast ratio of the defect/normal lateral wall were calculated for evaluation. The simulation was performed ten times, and all data were expressed as mean ± standard deviation. Tukey-Kramer test was used for statistical analysis.Results: In SPECT images with 360° acquisition, the CV with CS-IR (0.133 ± 0.006) was significantly lower than FBP (0.222 ± 0.003) and ML-EM (0.201 ± 0.003) (P < 0.05). Conversely, the FWHM with CS-IR was minimally deteriorated by 2.41 mm, compared to those of other reconstruction algorithms. The contrast ratio was not significantly different between the FBP and CS-IR. The results for 180° acquisition were almost the same as those of 360° acquisition.Conclusions: The uniformity with CS-IR was superior to that with FBP and ML-EM. CS-IR is expected to be useful for the reduction of acquisition time and calculation of myocardial flow reserve.