TY - JOUR T1 - <strong>18F-FDG Production and Quality Control (QC) Parameters Comparison in three different Automatic Synthesis Modules: An Experience of Commercial Centre</strong> JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 4123 LP - 4123 VL - 63 IS - supplement 2 AU - Madhusudan Vyas AU - Sandeep Sharma AU - D Sateesh AU - Naveen Kumar BC AU - V Gangadhara AU - Swatantra Singh AU - Sangram Behra AU - B.N. Kar Y1 - 2022/06/01 UR - http://jnm.snmjournals.org/content/63/supplement_2/4123.abstract N2 - 4123 Introduction: The radiopharmaceutical fluorodeoxyglucose (18F-FDG) is the most extensively utilised. It is mainly used in the diagnosis and staging of various cancers. Because of its wide range of applications, the utilisation of 18F-FDG has increased. For the synthesis of 18F-FDG and other radiopharmaceuticals, multiple types of make and models of automatic synthesis units are available on the market. We manufacture 18F-FDG on a large scale and sell it to consumers. For the standard manufacture of 18F-FDG, we installed three distinct types of autonomous synthesis modules in our facility: IBA – Synthera, Trasis – All-in-One, and Ora – Neptis. In this research, we attempted to compare various parameters of 18F-FDG synthesis modules in terms of yield and labelling efficiency using QC of 18F-FDG produced by all three synthesis modules as the 18F-FDG activity increased.Methods: We used disposable Cassette/IFP, Reagents and Precursor Mannose Triflate supplied by ABX, Germany. Huayi Isotopes, China supplied H218O with &gt;97% enrichment. Collected data for five productions of 18F-FDG for each synthesis module randomly and compared for yield, synthesis time and quality control parameters like pH, radiochemical purity, residual solvents, kryptofix, endotoxins etc.Results: We found that 18F-FDG Synthesis time was 21 to 24 minutes in all three. With a range of 12 Ci to 19 Ci of 18F-, the produced 18F-FDG yield was in the range of 60 to 66 %. Radiochemical purity obtained in all three was &gt;95%. Residual solvents (Acetonitrile and Ethanol) were comparatively less in the final product (18F-FDG) produced by IBA – Synthera, but in the other two also within limits specified as per United State Pharmacopeia.Conclusions: All three synthesis modules also produced 18F-FDG with high purity at higher input activity. The quality of 18F-FDG produced in all three synthesis modules follows specifications provided by United States Pharmacopeia. Synthesis time and yield are more or less similar in all three. ER -