RT Journal Article
SR Electronic
T1 <strong>A cross-comparison between HeartSee and PMOD for absolute quantification of myocardial blood flow in PET imaging</strong>
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 3379
OP 3379
VO 63
IS supplement 2
A1 Zhang, Chuxin
A1 Wang, Ruonan
A1 Hu, Yingqi
A1 Huangfu, Shihao
A1 Yao, Qi
A1 Li, Sijin
YR 2022
UL http://jnm.snmjournals.org/content/63/supplement_2/3379.abstract
AB 3379 Introduction: PMOD and HeartSee softwares are commonly used for absolute quantification of myocardial blood flow (MBF). The HeartSee model is a simple retention model which equivalents to one-tissue compartment model and in the PMOD the one-tissue compartment model (1TCM) is commonly used. The aim of this study was to cross-compare two software packages - HeartSee and PMOD - to quantify myocardial perfusion at global levels.Methods: Fifity-one cases underwent adenosine stress and rest 13N-ammonia studies (34 men and 17 women). Average age was 54.6&lt;u&gt;+&lt;/u&gt;7 y. Forty-three patients had coronary microvascular dysfunction (CMVD), 3 patients had obstructive coronary heart disease and 5 patients were after percutaneous coronary intervention (PCI). These patients were scanned by 13N-ammonia pet and processed by two different softwares. Compare the difference, correlation and consistency between HeartSee and PMOD in stress MBF, rest MBF and MFR.Results: When using PMOD and HeartSee,&lt;u style="font-family: Calibri;"&gt; &lt;/u&gt;there were significant differences for rest MBF (0.98(0.22)vs0.91(0.22),respectively;P&lt;0.05), stressMBF (2.41(0.44) vs 2.69(1.21), respectively; P&lt;0.05) and MFR (2.45(0.68) vs 2.9(1.04), respectively; P&lt; 0.05). However, The flow values and MFR values were highly correlated among the 2 packages (r=0.435,0.361and0.338, respectively; both P&lt;0.05). The agreement of stress MBF, rest MBF and MFR on global level were good (0.3 (-1.77 to 1.17), 0.08(-0.37 to 0.53), 0.47(-1.88 to 0.94), respectively).Conclusions: The global results agreed well between the two software packages despite higher rest MBF values by PMOD, higher stress MBF and MFR values by HeartSee. PMOD could be used interchangeably with HeartSee for 1TCM implementation on global levels.