TY - JOUR T1 - <strong>18F-FDG PET/CT manifestations of three Cases of Female Desmoplastic Small Round Cell Tumor</strong> JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 2691 LP - 2691 VL - 63 IS - supplement 2 AU - Yuping Zeng AU - Ping Chen Y1 - 2022/06/01 UR - http://jnm.snmjournals.org/content/63/supplement_2/2691.abstract N2 - 2691 Introduction: Purpose:To improve the diagnosis of female desmoplastic small round cell tumor (DSRCT) by presenting typical clinical cases. Reviewing the 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) manifestations of female DSRCT may help clinical nuclear medicine physicians provide more accurate interpretation and guidance for the proper management of patients.Background:Desmoplastic Small Round Cell Tumor(DSRCT)is a rare and highly aggressive soft tissue sarcoma that was first described by Gerald and Rosai in 1989. It predominantly affects young males with poor prognosis, and is usually confined to the abdominal cave, retroperitoneum or pelvic. Most patients experience non-specific symptoms such as abdominal discomfort, pain or distention, and corresponding system symptoms caused by tumor compression of surrounding tissues and organs. Thus the imaging of 18F-FDG PET/CT plays an important role in the its diagnosis. As DSRCT in females is extremely rare, the literature on it is limited.Methods: This report presents three female patients with DSRCT, who were admitted to hospital due to abdominal distension and are indicated abnormality with a significantly elevated serum CA-125 level. They all underwent the 18F-FDG PET/CT examination and were initially suspected of ovarian cancer metastasis,but the postoperative pathology confirmed them as DSRCT. The images of their 18F-FDG PET/CT are shown in the File Upload.Results: Generally, DSRCT is often widely disseminated in the abdominal cavity, retroperitoneum or pelvic cavity, and may cause extraperitoneal metastasis with liver, lymph nodes or lung commonly involved. Although CT manifestations of DSRCT are diverse, non-specific, it characteristically presents diffusely increased 18F-FDG uptake on PET. Nevertheless, given the rare occurrence in females of this disease, DSRCT is always excluded from the differential diagnosis in women with suspected mass, and is easily misinterpreted as ovarian cancer metastasis.Conclusions: Our cases further remind Nuclear medicine physicians that in a female patient with unknown widespread lesions in the abdominal cavity, retroperitoneum or pelvic cavity associated with increased 18F-FDG uptake, especially young females with highly increased serum CA-125 level, the possibility of DSRCT should be preferentially included in the diagnostic checklist. ER -