RT Journal Article SR Electronic T1 Artificial Intelligence Ecosystem in Nuclear Medicine: Opportunities, Challenges, and Responsibilities JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 2733 OP 2733 VO 63 IS supplement 2 A1 Saboury, Babak A1 Bradshaw, Tyler A1 Boellaard, Ronald A1 Buvat, Irene A1 Dutta, Joyita A1 Hatt, Mathieu A1 Jha, Abhinav A1 Li, Quanzheng A1 Liu, Chi A1 McMeekin, Helena A1 Morris, Michael A1 Scott, Peter A1 Siegel, Eliot A1 Sunderland, John A1 Wahl, Richard A1 Zuehlsdorff, Sven A1 Rahmim, Arman YR 2022 UL http://jnm.snmjournals.org/content/63/supplement_2/2733.abstract AB 2733 Introduction: Integration and implementation of artificial intelligence (AI) applications in the practice of nuclear medicine require careful analysis of potential opportunities and critical challenges. This comprehensive evaluation is inevitable in order to enhance patient care through innovation on one hand and to address concerns of all relevant stakeholders on the other.The AI ecosystem contains the total life-cycle of the application including data acquisition, model training and prototyping, production/testing, validation/evaluation, implementation and development, and post-deployment surveillance. Attention to all these steps through the lens of trustworthiness is essential. This educational exhibit explores the elements of trust in the healthcare ecosystem in the AI era while reviewing potential opportunities and critical challenges.Methods: This presentation summarizes the discussions of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) AI Task Force, which consists of various stakeholders and experts including physicists, computational imaging scientists, physicians, statisticians, and representatives from industry & regulatory agencies.Results: A.Opportunities:Diagnostic Imaging Image Generation Image Analysis Emerging Nuclear Imaging Approaches Radiopharmaceutical Therapies (RPTs) AI-driven theranostic drug discovery and labeling Precision Dosimetry Predictive Dosimetry and Digital Twins Clinical workflow: Increase throughput while maintaining excellenceB.Challenges: Development of AI Applications/Medical Devices Data Optimal Network Architecture Measurement and Communication of Uncertainty Clinically Impactful Use Cases Team Science Validation (Verification of performance Performance Profiling Through Task-Based Evaluations Guidelines for Validation Multi-Center Clinical Trial Network Ethical, Regulatory, and Legal Ambiguities Implementation of Clinical AI solutions & Post-Implementation Monitoring AI-Platform Barriers of Dissemination and Implementation of AI Technology in Medicine Post-implementation: change management & performance monitoring Trust and Trustworthiness C.Key Elements of Trustworthy AI Ecosystems:1) Human Agency, 2) Oversight, 3) Technical Robustness, 4) Safety and Accountability, 5) Security and Data Governance, 6) Predetermined Change Control Plan, 7) Diversity, Bias-awareness, Non-discrimination, and Fairness, 8) Stakeholder Participation, 9) Transparency and Explainability, 10) Sustainability of societal wellbeing, 11) Privacy, 12) Fairness and Supportive Context of ImplementationConclusions: The SNMMI AI Task Force has identified valuable opportunities to enhance the practice of nuclear medicine through AI-based innovation. In addition, critical pitfalls that commonly afflict AI algorithm development, evaluation, and implementation have been recognized. In the end, Task Force elaborated on the responsibilities of SNMMI and the nuclear medicine community to ensure the trustworthiness of these tools.