RT Journal Article SR Electronic T1 Radionuclides used in Nuclear Therapeutic Medicine: a brief history, properties and main relevant studies of radionuclides with mass number less than 100 JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 2696 OP 2696 VO 63 IS supplement 2 A1 Nathalia Minozzo A1 Ana Paula Schwarz A1 Gilberto Orengo YR 2022 UL http://jnm.snmjournals.org/content/63/supplement_2/2696.abstract AB 2696 Introduction: Despite the existence of constant studies and published works about radionuclides used in cancer therapies in nuclear medicine, the area lacks a direct compilation, which includes the physical properties of radiopharmaceuticals in therapy, their main uses in Therapeutic Nuclear Medicine and bring some of the main relevants researchs on the same document. In addition, in the academic environment, there is a need for a complete material, easily accessible and understandable about them. Also, the development of the work aimed to assist in the teaching didactics of younger students, facilitating their learning and serving as an incentive for interest in the area.Methods: The functions, properties and main applications of radionuclides with mass number less than 100 used in cancer therapies were studied through the main reliable online platforms that house these materials and published works. At the same time, the historical research regarding the use of these radionuclides was carried out on the same platforms, bringing information about relevant studies and their emergence. The compilation was constructed including physical properties, pre-clinical studies, clinical studies and main effective uses of each radionuclide, carried out through the literature searches previously made.Results: Among the results achieved, a table of all radionuclides used in nuclear medicine therapies found in bibliographies was prepared. It includes: the half-life, form of decay, corpuscular energy generated by this decay (which may be alpha or beta), the gamma radiation emitted, the electromagnetic energy emitted in the form of X-rays (when electronic capture occurs, mainly) and the form(s) of nuclide production found in the bibliographies. All data above 10% and below 99% has been approximated so that there are no decimal places. Gamma radiation and X-rays were considered when above 1%. In addition, an overview of the historical aspects and evolution of therapeutic nuclear medicine worldwide was made, addressing some of the main events that marked the advancement of treatments. A compilation of the most relevant research on the uses of nuclides with mass less than 100 was also carried out, namely: Phosphorus 32 (P32), Scandium 47 (Sc47), Copper 64 (Cu64), Copper 67 (Cu67), Gallium 67 (Ga67), Arsenic 77 (As77), Strontium 89 (Sr89) and Yttrium 90 (Y90).Conclusions: The work allowed the understanding of the importance of Therapeutic Nuclear Medicine, together with the need for more inclusive and easy-to-understand materials, so that there is greater interest from students and professionals in the area, generating greater popularity of the subject. After the dedication to the study of radionuclides used in the area around the world, anciently and today, it was necessary to study their physical and pharmacological properties. The historical study also proved to be of extreme importance, given the lack of published materials that include the dates of the rise of each radionuclide in the health industry. It is expected that the materials produced will serve as support for students in the area, who seek a better understanding of the topic without the need to seek individual materials outside their interest, many approaching only one branch of the many possible ones. Once again, the need to build similar materials of easy access and understanding about therapeutic nuclear medicine is highlighted, with the potential to instigate many in the future to seek more about this area that has so much to offer.