PT  - JOURNAL ARTICLE
AU  - Chen, Bi-Xi
AU  - Gong, Juan-Ni
AU  - Xing, Hai-Qun
AU  - Yang, Yuan-Hua
AU  - Huo, Li
AU  - Yang, Min-Fu
TI  - <strong>Pulmonary artery imaging with 68Ga-FAPI-04 in patients with chronic thromboembolic pulmonary hypertension</strong>
DP  - 2022 Jun 01
TA  - Journal of Nuclear Medicine
PG  - 3357--3357
VI  - 63
IP  - supplement 2
4099  - http://jnm.snmjournals.org/content/63/supplement_2/3357.short
4100  - http://jnm.snmjournals.org/content/63/supplement_2/3357.full
SO  - J Nucl Med2022 Jun 01; 63
AB  - 3357 Introduction: The feasibility and significance of imaging pulmonary artery (PA) remodeling with 68Ga-fibroblast activating protein inhibitor (FAPI) in chronic thromboembolic pulmonary hypertension (CTEPH) patients have not been addressed. Methods: 68Ga-FAPI uptake in PA and ascending artery was evaluated in 13 CTEPH patients and 13matched non-CTEPH controls. The correlations of PA 68Ga-FAPI uptake and remodeling parameters derived from right heart catheterization (RHC) were further analyzed.Results: Of the 13 CTEPH patients, nine (69%) showed visually enhanced 68Ga-FAPI-04 uptake, whereas no control subject had increased 68Ga-FAPI-04 uptake in PA. The prevalence of enhanced uptake in the main, lobar, and segmental PAs were 45% (17/38), 33% (16/48), and 28% (44/159), respectively. 68Ga-FAPI-04 activity of PA was positively correlated with pulmonary arterial diastolic pressure (r = 0.571, P = 0.041).Conclusions: CTEPH patients may have increased 68Ga-FAPI-04 uptake in PA, and the 68Ga-FAPI-04 activity of PA is positively correlated with pulmonary arterial diastolic pressure.