TY - JOUR T1 - <strong>Preventive and palliative effects of basil tea on salivary gland disorders associated with radioactive iodine therapy</strong> JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 3105 LP - 3105 VL - 63 IS - supplement 2 AU - Michihiro Nakayama AU - Kenta Nomura AU - Akiko Oya AU - Atsutaka Okizaki Y1 - 2022/06/01 UR - http://jnm.snmjournals.org/content/63/supplement_2/3105.abstract N2 - 3105 Introduction: Radioactive iodine (RAI) is taken up intracellularly via sodium iodide cotransporters (NIS), but is also taken up by salivary glands that contain NIS in addition to thyroid-derived cells. Accordingly, a frequent side effect of RI therapy is sialadenitis. In the acute stage of sialadenitis, swelling and pain of the major salivary glands occur within a few days after taking I-131. It may resolve spontaneously, but in the chronic phase, it can cause xerostomia, which significantly impairs QOL.Basil has been used as a food for a long time and has a high safety profile. Basil has been used as a food for a long time and is safe. Basil contains anethole, which promotes digestive function, and cinerol, which has antibacterial activity. Linalool, which has a sweet scent like lilies, has a relaxing and appetite stimulating effect. The most common side effects of RAI therapy include direct symptoms such as swelling and pain of the salivary glands and hospitalization stress. The prevention and alleviation of these side effects is one of the essential measures to improve the patient environment for nurses who are in constant contact with patients. The use of basil tea, which has a variety of efficacies, may be effective in improving the therapeutic environment of patients during the RAI treatment process. The purpose of this study was to evaluate the effect of basil tea on saliva secretion and improvement of oral environment during the treatment period.Methods: Salivary function tests, salivary gland scintigraphy, State-Trait Anxiety Inventory (STAI), and basil tea intervention were explained and written consent was obtained prior to admission or on the first day of admission.The intervention period was 5 days from the day of RI treatment. For the intervention, 2 g of basil tea bag was brewed with 180 ml of hot water (administered by a health care worker) and taken after each meal. We used 2g individual basil tea bags to avoid imbalance in dosage. Salivary function tests (caries, occult blood, protein, and ammonia levels), salivary gland scintigraphy, and STAI were performed before and after treatment.The results of the study were compared between the basil tea intervention group (Group A) and the non-intervention group (Group B) in a randomized controlled trial. The results were compared between the two groups. Based on the results obtained, a t-test or Wilcoxon's rank sum test was performed to prove clinical efficacy, depending on whether a parametric distribution could be assumed.Results: A total of 42 subjects (21 in the intervention group and 21 in the non-intervention group) participated in the study.(1) Salivary gland scintigraphyThe washout ratio of bilateral submandibular glands (Figs. 1 and 2) was significantly lower in the non-intervention group than in the intervention group. In the bilateral parotid glands (Figs. 3 and 4), there was no significant difference, but the non-intervention group tended to decrease more than the intervention group. This suggests that drinking basil tea may have prevented the acute salivary inflammation disorder.(2) STAIState Anxiety (Fig. 5) and Trait Anxiety (Fig. 6) were significantly decreased in the intervention group after treatment, suggesting a decrease in stress.(3) Salivary function testThe objective evaluation of the oral environment using the oral environment test (SillHa: ARKRAY, Inc., JAPAN) showed that the amount of dental caries as an indicator of dental health (Fig. 7), ammonia concentration as an indicator of oral cleanliness (Fig. 8), protein as an indicator of gum health (Fig. 9), and occult blood (Fig. 10), all of which were significantly lower in the intervention group after treatment, suggesting that basil tea drinking may prevent deterioration of the oral environment.Conclusions: It was suggested that drinking basil tea may prevent or alleviate the deterioration of the oral environment associated with acute salivary gland disorders associated with RAI therapy. ER -