TY - JOUR T1 - The Influence of Specific Activity on the Biodistribution of <sup>18</sup>F-rhPSMA-7.3: A Retrospective Analysis of Clinical PET Data JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 742 LP - 745 DO - 10.2967/jnumed.121.262471 VL - 63 IS - 5 AU - Thomas Langbein AU - Alexander Wurzer AU - Andrei Gafita AU - Andrew Robertson AU - Hui Wang AU - Ayça Arçay AU - Michael Herz AU - Hans-Juergen Wester AU - Wolfgang A. Weber AU - Matthias Eiber Y1 - 2022/05/01 UR - http://jnm.snmjournals.org/content/63/5/742.abstract N2 - We investigated whether the time between synthesis and injection and the resulting decrease in specific activity affects the normal-organ and tumor uptake of the PSMA ligand 18F-rhPSMA-7.3 in patients with prostate cancer. Methods: The biodistribution of 18F-rhPSMA-7.3 on PET/CT scans obtained with a high specific activity (median, 178.9 MBq/µg; n = 42) and a low specific activity (median, 19.3 MBq/µg; n = 42) was compared. Results: Tracer uptake by the parotid gland, submandibular gland, and spleen was moderately but significantly lower in the low-specific-activity group than in the high-specific-activity group (median SUVmean, 16.7 vs. 19.2; 18.1 vs. 22.3; and 7.8 vs. 9.6, respectively). No other statistically significant differences were found for normal organs or tumor lesions. Conclusion: A 10-fold decrease in specific activity has only minor effects on the biodistribution of 18F-rhPSMA-7.3. These findings suggest that 18F-labeled PSMA ligands can be centrally produced and shipped to PET clinics in a similar way to 18F-FDG. ER -