RT Journal Article
SR Electronic
T1 A Guide to ComBat Harmonization of Imaging Biomarkers in Multicenter Studies
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 172
OP 179
DO 10.2967/jnumed.121.262464
VO 63
IS 2
A1 Orlhac, Fanny
A1 Eertink, Jakoba J.
A1 Cottereau, Anne-Ségolène
A1 Zijlstra, Josée M.
A1 Thieblemont, Catherine
A1 Meignan, Michel
A1 Boellaard, Ronald
A1 Buvat, Irène
YR 2022
UL http://jnm.snmjournals.org/content/63/2/172.abstract
AB The impact of PET image acquisition and reconstruction parameters on SUV measurements or radiomic feature values is widely documented. This scanner effect is detrimental to the design and validation of predictive or prognostic models and limits the use of large multicenter cohorts. To reduce the impact of this scanner effect, the ComBat method has been proposed and is now used in various contexts. The purpose of this article is to explain and illustrate the use of ComBat based on practical examples. We also give examples in which the ComBat assumptions are not met and, thus, in which ComBat should not be used.