PT  - JOURNAL ARTICLE
AU  - Orlhac, Fanny
AU  - Eertink, Jakoba J.
AU  - Cottereau, Anne-Ségolène
AU  - Zijlstra, Josée M.
AU  - Thieblemont, Catherine
AU  - Meignan, Michel
AU  - Boellaard, Ronald
AU  - Buvat, Irène
TI  - A Guide to ComBat Harmonization of Imaging Biomarkers in Multicenter Studies
AID  - 10.2967/jnumed.121.262464
DP  - 2022 Feb 01
TA  - Journal of Nuclear Medicine
PG  - 172--179
VI  - 63
IP  - 2
4099  - http://jnm.snmjournals.org/content/63/2/172.short
4100  - http://jnm.snmjournals.org/content/63/2/172.full
SO  - J Nucl Med2022 Feb 01; 63
AB  - The impact of PET image acquisition and reconstruction parameters on SUV measurements or radiomic feature values is widely documented. This scanner effect is detrimental to the design and validation of predictive or prognostic models and limits the use of large multicenter cohorts. To reduce the impact of this scanner effect, the ComBat method has been proposed and is now used in various contexts. The purpose of this article is to explain and illustrate the use of ComBat based on practical examples. We also give examples in which the ComBat assumptions are not met and, thus, in which ComBat should not be used.