PT - JOURNAL ARTICLE AU - Wakfie-Corieh, Cristina Gamila AU - Ferrando-Castagnetto, Federico AU - García, Alba María Blanes AU - García-Esquinas, Marta García AU - Candil, Aída Ortega AU - Rey, Cristina Rodríguez AU - Cabrera-Martín, María Nieves AU - Cano, Ana Delgado AU - Delgado, José Luis Carreras TI - Incidental Findings Suggestive of COVID-19 Pneumonia in Oncologic Patients Undergoing <sup>18</sup>F-FDG PET/CT Studies: Association Between Metabolic and Structural Lung Changes AID - 10.2967/jnumed.121.261915 DP - 2022 Feb 01 TA - Journal of Nuclear Medicine PG - 274--279 VI - 63 IP - 2 4099 - http://jnm.snmjournals.org/content/63/2/274.short 4100 - http://jnm.snmjournals.org/content/63/2/274.full SO - J Nucl Med2022 Feb 01; 63 AB - Although the novel coronavirus disease 2019 (COVID-19) can present as nonspecific clinical forms, subclinical cases represent an important route of transmission and a significant source of mortality, mainly in high-risk subpopulations such as cancer patients. A deeper knowledge of the metabolic shift in cells infected with severe acute respiratory syndrome coronavirus 2 could provide new insights about its pathogenic and host response and help to diagnose pulmonary involvement. We explored the potential added diagnostic value of 18F-FDG PET/CT scans in asymptomatic cancer patients with suspected COVID-19 pneumonia by investigating the association between metabolic and structural changes in the lung parenchyma. Methods: 18F-FDG PET/CT studies acquired between February 19 and May 29, 2020, were reviewed to identify those cancer patients with incidental findings suggestive of COVID-19 pneumonia. PET studies were interpreted through qualitative (visual) and semiquantitative (measurement of SUVmax) analysis evaluating lung findings. Several characteristic signs of COVID-19 pneumonia on CT were described as COVID-19 Reporting and Data System (CO-RADS) categories (1–6). After comparing the SUVmax of pulmonary infiltrates among different CO-RADS categories, we explored the best potential cutoffs for pulmonary SUVmax against CO-RADS categories as the gold standard result to eliminate the possibility that the diagnosis of COVID-19 pneumonia exists. Results: On multimodal PET/CT imaging, CT signs classified as CO-RADS category 5 or 6 were found in 16 of 41 (39%) oncologic patients. SUVmax was higher in patients with categories 5 and 6 than in patients with category 4 (6.17 ± 0.82 vs. 3.78 ± 0.50, P = 0.04) or categories 2 and 3 (3.59 ± 0.41, P = 0.01). A specificity of 93.8% (95% CI, 71.7%–99.7%) and an accuracy of 92.9% were obtained when combining a CO-RADS score of 5 or 6 with an SUVmax of 2.45 in pulmonary infiltrates. Conclusion: In asymptomatic cancer patients, the metabolic activity in lung infiltrates is closely associated with several combined tomographic changes characteristic of COVID-19 pneumonia. Multimodal 18F-FDG PET/CT imaging could provide additional information during early diagnosis in selected predisposed patients during the pandemic. The prognostic implications of simultaneous radiologic and molecular findings in cancer patients and other subpopulations at high risk for COVID-19 pneumonia deserve further evaluation in prospective research.