PT  - JOURNAL ARTICLE
AU  - Chao Li
AU  - Chaozhe Han
AU  - Shao Duan
AU  - Ping Li
AU  - Israt S. Alam
AU  - Zunyu Xiao
TI  - Visualizing T-Cell Responses: The T-Cell PET Imaging Toolbox
AID  - 10.2967/jnumed.121.261976
DP  - 2022 Feb 01
TA  - Journal of Nuclear Medicine
PG  - 183--188
VI  - 63
IP  - 2
4099  - http://jnm.snmjournals.org/content/63/2/183.short
4100  - http://jnm.snmjournals.org/content/63/2/183.full
SO  - J Nucl Med2022 Feb 01; 63
AB  - T lymphocytes are key mediators of the adaptive immune response. Inappropriate or imbalanced T-cell responses are underlying factors in cancer progression, allergy, and other immune disorders. Monitoring the spatiotemporal dynamics of T cells and their functional status has the potential to provide unique biologic insights into health and disease. Noninvasive PET imaging represents an ideal whole-body modality for achieving this goal. With the appropriate PET imaging probes, T-cell dynamics can be monitored in vivo with high specificity and sensitivity. Herein, we provide a comprehensive overview of the applications of this state-of-the-art T-cell PET imaging toolbox and the potential it has to improve the clinical management of cancer immunotherapy and T-cell–driven diseases. We also discuss future directions and prospects for clinical translation.