PT  - JOURNAL ARTICLE
AU  - Capala, Jacek
AU  - Graves, Stephen A.
AU  - Scott, Aaron
AU  - Sgouros, George
AU  - James, Sara St.
AU  - Zanzonico, Pat
AU  - Zimmerman, Brian E.
TI  - Dosimetry for Radiopharmaceutical Therapy: Current Practices and Commercial Resources
AID  - 10.2967/jnumed.121.262749
DP  - 2021 Dec 01
TA  - Journal of Nuclear Medicine
PG  - 3S--11S
VI  - 62
IP  - Supplement 3
4099  - http://jnm.snmjournals.org/content/62/Supplement_3/3S.short
4100  - http://jnm.snmjournals.org/content/62/Supplement_3/3S.full
SO  - J Nucl Med2021 Dec 01; 62
AB  - With the ongoing dramatic growth of radiopharmaceutical therapy, research and development in internal radiation dosimetry continue to advance both at academic medical centers and in industry. The basic paradigm for patient-specific dosimetry includes administration of a pretreatment tracer activity of the therapeutic radiopharmaceutical; measurement of its time-dependent biodistribution; definition of the pertinent anatomy; integration of the measured time–activity data to derive source-region time-integrated activities; calculation of the tumor, organ-at-risk, and/or whole-body absorbed doses; and prescription of the therapeutic administered activity. This paper provides an overview of the state of the art of patient-specific dosimetry for radiopharmaceutical therapy, including current methods and commercially available software and other resources.