RT Journal Article
SR Electronic
T1 PSMA PET validates higher rates of metastatic disease for European Association of Urology Biochemical Recurrence Risk Groups: an international multicenter study
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.121.262821
DO 10.2967/jnumed.121.262821
A1 Justin Ferdinandus
A1 Wolfgang Peter Fendler
A1 Andrea Farolfi
A1 Samuel Washington
A1 Osama Mohammad
A1 Miguel Hernandez Pampaloni
A1 Peter J Scott
A1 Melissa Rodnick
A1 Benjamin L Viglianti
A1 Matthias Eiber
A1 Ken Herrmann
A1 Johannes Czernin
A1 Wesley Robert Armstrong
A1 Jeremie Calais
A1 Thomas A. Hope
A1 Morand A. Piert
YR 2021
UL http://jnm.snmjournals.org/content/early/2021/10/07/jnumed.121.262821.abstract
AB Background: The European Association of Urology (EAU) Prostate Cancer Guidelines Panel recommends risk groups for biochemically recurrent prostate cancer (BCR) to identify men at high risk of progression or metastatic disease. Recent United States Food and Drug Administration approval for 68Ga-PSMA-11 and growing availability of PSMA-directed PET imaging (PSMA PET) will impact disease localization in majority of men with BCR. We determined the rates of local and metastatic disease in recurrent and persistent prostate cancer stratified by EAU BCR risk groups and biochemical persistence (BCP). Patients and Methods: Patients with BCR/BCP were enrolled under the same prospective clinical trial protocol conducted at three sites (n = 1777, 91%; UCLA n = 662, NCT02940262; UCSF n = 508, NCT03353740; Michigan, n = 607, NCT03396874); 183 patients with BCP from Universities of Essen, Bologna, and Munich (TUM) were included retrospectively. Patients with BCR had to have sufficient data to determine EAU risk score. Multivariate, binomial logistic regression models were applied to assess independent predictors of M1 disease. Results: A total of 1960 patients were included. Post-RP EAU BCR low risk, EAU BCR high risk, and BCP groups yield distant metastatic (M1) detection in 43/176 (24%), 342/931 (37%), and 154/386 (40%) of patients. For post-RT EAU BCR low risk and EAU BCR high risk groups, M1 detection rate was 113/309 (37%) and 110/158 (70%), respectively. BCP, high risk BCR and higher levels of serum PSA were significantly associated with PSMA PET M1 disease in multivariate regression analysis. PSMA-PET revealed no disease in 25% and locoregional only disease in 33% of patients with post-RP or post-RT EAU BCR high risk. Conclusion: Our findings support the new EAU classification; EAU BCR high-risk groups have higher rates of metastatic disease on PSMA PET than the low-risk groups. Discordant subgroups, including metastatic disease in low risk and no disease in high risk patients warrant inclusion of PSMA PET stage to refine risk assessment.