TY - JOUR T1 - Predicting the outcome of epilepsy surgery by covariance pattern analysis of ictal perfusion SPECT JF - Journal of Nuclear Medicine JO - J Nucl Med DO - 10.2967/jnumed.121.262702 SP - jnumed.121.262702 AU - Jila Taherpour AU - Marian Jaber AU - Berthold Voges AU - Ivayla Apostolova AU - Thomas Sauvigny AU - Patrick M House AU - Michael Lanz AU - Matthias Lindenau AU - Susanne Klutmann AU - Tobias Martens AU - Stefan Stodieck AU - Ralph Buchert Y1 - 2021/09/01 UR - http://jnm.snmjournals.org/content/early/2021/09/30/jnumed.121.262702.abstract N2 - Previous studies on the utility of specific perfusion patterns in ictal brain perfusion SPECT for predicting the outcome of temporal lobe epilepsy surgery used qualitative visual pattern classification, semi-quantitative region-of-interest analysis or conventional univariate voxel-based testing, which are limited by intra- and inter-rater variability and/or low sensitivity to capture functional interactions among brain regions. The present study performed covariance pattern analysis of ictal perfusion SPECT using the Scaled Subprofile Model for unbiased identification of predictive covariance patterns. Methods: The study retrospectively included 18 responders to temporal lobe epilepsy surgery (Engel I-A at 12 months follow-up) and 18 non-responders (≥ Engel I-B). Ictal SPECT images were analyzed with the Scaled Subprofile Model blinded to group membership for unbiased identification of the 16 covariance patterns explaining the highest proportion of variance in the whole data set. Individual expression scores of the covariance patterns were evaluated for predicting seizure freedom after temporal lobe surgery by ROC analysis. Kaplan-Meier analysis including all available follow-up data (up to 60 months after surgery) was also performed. Results: Amongst the 16 covariance patterns only one showed a different expression between responders and non-responders (P = 0.03). This ‘favorable ictal perfusion pattern’ resembled the typical ictal perfusion pattern in temporomesial epilepsy. The expression score of the pattern provided an area of 0.744 (95%-confidence interval 0.577-0.911, P = 0.004) under the ROC curve. Kaplan-Meier analysis revealed a statistical trend towards longer seizure freedom in patients with positive expression score (P = 0.06). The median estimated seizure free time was 48 months in patients with positive expression score versus 6 months in patients with negative expression score. Conclusion: The expression of the ‘favorable ictal perfusion pattern’ identified by covariance analysis of ictal brain perfusion SPECT provides independent (from demographical and clinical variables) information for the prediction of seizure freedom after temporal lobe epilepsy surgery. The expression of this pattern is easily computed for new ictal SPECT images and, therefore, might be used to support the decision for or against temporal lobe surgery in clinical patient care. ER -