RT Journal Article
SR Electronic
T1 A guide to ComBat harmonization of imaging biomarkers in multicenter studies
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.121.262464
DO 10.2967/jnumed.121.262464
A1 Fanny Orlhac
A1 Jakoba J Eertink
A1 Anne-Segolene Cottereau
A1 Josee M. Zijlstra
A1 Catherine Thieblemont
A1 Michel A. Meignan
A1 Ronald Boellaard
A1 Irene Buvat
YR 2021
UL http://jnm.snmjournals.org/content/early/2021/09/15/jnumed.121.262464.abstract
AB The impact of PET image acquisition and reconstruction parameters on SUV measurements or radiomic feature values is widely documented. This "scanner" effect is detrimental to the design and validation of predictive or prognostic models and limits the use of large multicenter cohorts. To reduce the impact of this scanner effect, the ComBat method has been proposed and is now used in various contexts. The purpose of this article is to explain and illustrate the use of ComBat based on practical examples. We also give examples in which the ComBat assumptions are not met; thus, ComBat should not be used.