RT Journal Article SR Electronic T1 A guide to ComBat harmonization of imaging biomarkers in multicenter studies JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP jnumed.121.262464 DO 10.2967/jnumed.121.262464 A1 Orlhac, Fanny A1 Eertink, Jakoba J A1 Cottereau, Anne-Segolene A1 Zijlstra, Josee M. A1 Thieblemont, Catherine A1 Meignan, Michel A. A1 Boellaard, Ronald A1 Buvat, Irene YR 2021 UL http://jnm.snmjournals.org/content/early/2021/09/15/jnumed.121.262464.abstract AB The impact of PET image acquisition and reconstruction parameters on SUV measurements or radiomic feature values is widely documented. This "scanner" effect is detrimental to the design and validation of predictive or prognostic models and limits the use of large multicenter cohorts. To reduce the impact of this scanner effect, the ComBat method has been proposed and is now used in various contexts. The purpose of this article is to explain and illustrate the use of ComBat based on practical examples. We also give examples in which the ComBat assumptions are not met; thus, ComBat should not be used.