TY - JOUR T1 - A guide to ComBat harmonization of imaging biomarkers in multicenter studies JF - Journal of Nuclear Medicine JO - J Nucl Med DO - 10.2967/jnumed.121.262464 SP - jnumed.121.262464 AU - Fanny Orlhac AU - Jakoba J Eertink AU - Anne-Segolene Cottereau AU - Josee M. Zijlstra AU - Catherine Thieblemont AU - Michel A. Meignan AU - Ronald Boellaard AU - Irene Buvat Y1 - 2021/09/01 UR - http://jnm.snmjournals.org/content/early/2021/09/15/jnumed.121.262464.abstract N2 - The impact of PET image acquisition and reconstruction parameters on SUV measurements or radiomic feature values is widely documented. This "scanner" effect is detrimental to the design and validation of predictive or prognostic models and limits the use of large multicenter cohorts. To reduce the impact of this scanner effect, the ComBat method has been proposed and is now used in various contexts. The purpose of this article is to explain and illustrate the use of ComBat based on practical examples. We also give examples in which the ComBat assumptions are not met; thus, ComBat should not be used. ER -