RT Journal Article
SR Electronic
T1 Latest advances in imaging oxidative stress in cancer
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.120.256974
DO 10.2967/jnumed.120.256974
A1 Greenwood, Hannah E
A1 Witney, Timothy H
YR 2021
UL http://jnm.snmjournals.org/content/early/2021/08/26/jnumed.120.256974.abstract
AB Oxidative stress is the imbalance of harmful reactive oxygen species (ROS) and the action of neutralizing antioxidant mechanisms. If left unchecked, the deleterious effects of oxidative stress results in damage to DNA, proteins, and membranes, ultimately resulting in cell death. Tumors are highly proliferative and consequently generate high levels of mitochondrial ROS. To compensate and maintain redox homeostasis, cancer cells upregulate protective antioxidant pathways, which are further amplified in drug-resistant tumors. This review provides an overview of the latest molecular imaging techniques designed to image oxidative stress in cancer. New probes are now able to assess heterogeneous ROS and antioxidant production within tumors and across lesions. Together, the non-invasive imaging of these dynamic processes holds great promise for treatment response monitoring, prediction of drug resistance, and may provide insight into the metastatic potential of tumors.