RT Journal Article SR Electronic T1 PET/CT-Guided Biopsy of Suspected Lung Lesions Requires Less Rebiopsy Than CT-Guided Biopsy Due to Inconclusive Results JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1057 OP 1061 DO 10.2967/jnumed.120.252403 VO 62 IS 8 A1 Juliano J. Cerci A1 Mateos Bogoni A1 Rodrigo J. Cerci A1 Margaret Masukawa A1 Carlos C.P. Neto A1 Cassiano Krauzer A1 Stefano Fanti A1 Danielle G. Sakamoto A1 Renan B. Barreiros A1 Cristina Nanni A1 João V Vitola YR 2021 UL http://jnm.snmjournals.org/content/62/8/1057.abstract AB The purpose of this study was to compare 18F-FDG PET/CT and CT performance in guiding percutaneous biopsies with histologic confirmation of lung lesions. Methods: We prospectively evaluated 341 patients, of whom 216 underwent 18F-FDG PET/CT–guided biopsy and 125 underwent CT-guided biopsy. The pathology results, lesion size, complications, and rebiopsy rate in the 2 groups were evaluated. Results: Of the 216 biopsies with PET/CT guidance, histology demonstrated 170 lesions (78.7%) to be malignant and 46 (21.3%) to be benign. In the CT-guided group, of 125 lesions, 77 (61.6%) were malignant and 48 (38.4%) were benign (P = 0.001). Inconclusive results prompted the need for a second biopsy in 18 patients: 13 of 125 (10.4%) in the CT group and 5 of 216 (2.3%) in PET group (P = 0.001). Complications were pneumothorax (13.2%), hemothorax (0.8%), and hemoptysis (0.6%). No life-threatening adverse events or fatalities were reported. The difference in complication rates between the 2 groups was not significant (P = 0.6). Malignant lesions showed a greater mean size than benign lesions regardless of the group (P = 0.015). Conclusion: PET/CT-guided biopsy of lung lesions led to fewer inconclusive biopsies than CT-guided biopsy, with similar complication rates.