PT  - JOURNAL ARTICLE
AU  - Cerci, Juliano J.
AU  - Bogoni, Mateos
AU  - Cerci, Rodrigo J.
AU  - Masukawa, Margaret
AU  - Neto, Carlos C.P.
AU  - Krauzer, Cassiano
AU  - Fanti, Stefano
AU  - Sakamoto, Danielle G.
AU  - Barreiros, Renan B.
AU  - Nanni, Cristina
AU  - Vitola, João V
TI  - PET/CT-Guided Biopsy of Suspected Lung Lesions Requires Less Rebiopsy Than CT-Guided Biopsy Due to Inconclusive Results
AID  - 10.2967/jnumed.120.252403
DP  - 2021 Aug 01
TA  - Journal of Nuclear Medicine
PG  - 1057--1061
VI  - 62
IP  - 8
4099  - http://jnm.snmjournals.org/content/62/8/1057.short
4100  - http://jnm.snmjournals.org/content/62/8/1057.full
SO  - J Nucl Med2021 Aug 01; 62
AB  - The purpose of this study was to compare 18F-FDG PET/CT and CT performance in guiding percutaneous biopsies with histologic confirmation of lung lesions. Methods: We prospectively evaluated 341 patients, of whom 216 underwent 18F-FDG PET/CT–guided biopsy and 125 underwent CT-guided biopsy. The pathology results, lesion size, complications, and rebiopsy rate in the 2 groups were evaluated. Results: Of the 216 biopsies with PET/CT guidance, histology demonstrated 170 lesions (78.7%) to be malignant and 46 (21.3%) to be benign. In the CT-guided group, of 125 lesions, 77 (61.6%) were malignant and 48 (38.4%) were benign (P = 0.001). Inconclusive results prompted the need for a second biopsy in 18 patients: 13 of 125 (10.4%) in the CT group and 5 of 216 (2.3%) in PET group (P = 0.001). Complications were pneumothorax (13.2%), hemothorax (0.8%), and hemoptysis (0.6%). No life-threatening adverse events or fatalities were reported. The difference in complication rates between the 2 groups was not significant (P = 0.6). Malignant lesions showed a greater mean size than benign lesions regardless of the group (P = 0.015). Conclusion: PET/CT-guided biopsy of lung lesions led to fewer inconclusive biopsies than CT-guided biopsy, with similar complication rates.