TY - JOUR T1 - The European Association of Urology Biochemical Recurrence Risk Groups Predict Findings on PSMA PET in Patients with Biochemically Recurrent Prostate Cancer after Radical Prostatectomy JF - Journal of Nuclear Medicine JO - J Nucl Med DO - 10.2967/jnumed.121.262411 SP - jnumed.121.262411 AU - LIANG DONG AU - Yun Su AU - Yinjie Zhu AU - Mark C. Markowski AU - Mei Xin AU - Michael A. Gorin AU - Baijun Dong AU - Jiahua Pan AU - Martin G. Pomper AU - Jianjun Liu AU - Kenneth J Pienta AU - Wei Xue AU - Steven P. Rowe Y1 - 2021/07/01 UR - http://jnm.snmjournals.org/content/early/2021/07/29/jnumed.121.262411.abstract N2 - Purpose: To evaluate the association of a new biochemical recurrence (BCR) risk stratification system with PSMA-targeted PET/CT findings. Methods: Two prospective studies that included patients with BCR were pooled. Findings on PSMA PET were catalogued. Patients were characterized according to the European Association of Urology (EAU) BCR risk categories. Univariable and multivariable analyses were carried out by logistic regression. Results: 145 patients were included (45 low-risk and 100 high-risk). High-risk BCR patients had a higher positive rate when compared to low-risk (82.0% vs. 48.9%; P < 0.001), and reached independent predictor status for positive PSMA PET/CT scan on multivariable logistic regression (OR 6.73, 95% CI 2.41-18.76; P < 0.001). The AUC using the combination of BCR risk group and PSA was higher than PSA alone (0.834 vs. 0.759, P = 0.015). Conclusion: The EAU BCR risk group defines the best candidates who can benefit from a PSMA PET/CT scan when BCR occurs. ER -