RT Journal Article SR Electronic T1 Evolution of 18F-FDG-PET/CT findings in patients following COVID-19 pneumonia: An Initial Investigation JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP jnumed.121.262296 DO 10.2967/jnumed.121.262296 A1 Andrew Thornton A1 Francesco Fraioli A1 Simon Wan A1 Helen S Garthwaite A1 Balaji Ganeshan A1 Robert Ian Shortman A1 Raymond Endozo A1 Stefan Voo A1 Irfan Kayani A1 Deena Neriman A1 Leon Menezes A1 Jamshed B. Bomanji A1 Toby Hillman A1 Melissa Heightman A1 Joanna C Porter A1 Ashley M Groves YR 2021 UL http://jnm.snmjournals.org/content/early/2021/07/16/jnumed.121.262296.abstract AB Background: The evolution of pulmonary 18F-FDG uptake is unknown in patients with pneumonia due to SARS-CoV-2 (COVID-19 pneumonia) and in those with persistent respiratory symptoms post-COVID-19 termed Post-COVID-19 Lung-Disease (PCLD). The aim of this study was to assess the temporal evolution of pulmonary 18F-FDG uptake and identify a potential role for the use of 18F-FDG-PET/CT imaging in the management of these patients. Methods: Clinical data and CT imaging of all patients that underwent 18F-FDG-PET/CT imaging at UCLH, Lon-don during the UK pandemic were reviewed to find evidence of active or recovered SARS-CoV-2 infection. Results of PCR tests were used where available. Patients were divided in to acute (early and late) COVID-19 pneumonia, PCLD and asymptomatic recovery. 18F-FDG uptake in the lungs was measured as a target-to-background ratio (SUVmax/SUVmin) TBRlung which was compared to temporal-stage and plasma CRP. Results: There were 50 patients in total (median 61y, range 18–87y, 32-male): 23 incidental acute COVID-19 pneumonia cases identified retrospectively (8 Early, 15 Late), 9 asymptomatic recovered patients, and 18 cases performed for PCLD. In acute COVID-19 patients <3 weeks since disease onset TBRlung was strongly correlated with time since disease onset (rs=0.81, p<0.001).