RT Journal Article
SR Electronic
T1 Cardiac β-Adrenergic Receptor Downregulation, Evaluated by Cardiac PET, in Chronotropic Incompetence
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 996
OP 998
DO 10.2967/jnumed.120.253419
VO 62
IS 7
A1 Goto, Toshihiko
A1 Kikuchi, Shohei
A1 Mori, Kento
A1 Nakayama, Takafumi
A1 Fukuta, Hidekatsu
A1 Seo, Yoshihiro
A1 Narita, Hitomi
A1 Iida, Akihiko
A1 Ohte, Nobuyuki
YR 2021
UL http://jnm.snmjournals.org/content/62/7/996.abstract
AB The mechanism of chronotropic incompetence (CTI), which has been associated with autonomic dysfunction, has not been elucidated in patients without heart failure (HF). Methods: Cardiac PET using 11C-CGP12177 was performed to investigate the cardiac β-adrenergic receptor density (β-ARD) in 13 patients with CTI without HF and 6 healthy controls. The maximum number of available specific 11C-CGP12177 binding sites per gram of tissue was calculated in regions of interest using an established graphical method. Results: Peak heart rate was significantly lower in CTI patients than in controls (116.9 ± 11.0 vs. 154.8 ± 14.4 beats/min, P < 0.001). β-ARD of the total myocardium was significantly lower in CTI patients than in controls (4.3 ± 1.7 vs. 7.0 ± 1.7 pmol/mL, P = 0.005). Conclusion: β-adrenergic receptor downregulation was demonstrated in patients with CTI without HF. Decreased β-ARD is a common feature in patients with CTI, with or without HF.