RT Journal Article SR Electronic T1 Toward a Universal Readout for 18F-Labeled Amyloid Tracers: The CAPTAINs Study JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 999 OP 1005 DO 10.2967/jnumed.120.250290 VO 62 IS 7 A1 Gérard N. Bischof A1 Peter Bartenstein A1 Henryk Barthel A1 Bart van Berckel A1 Vincent Doré A1 Thilo van Eimeren A1 Norman Foster A1 Jochen Hammes A1 Adriaan A. Lammertsma A1 Satoshi Minoshima A1 Chris Rowe A1 Osama Sabri A1 John Seibyl A1 Koen Van Laere A1 Rik Vandenberghe A1 Victor Villemagne A1 Igor Yakushev A1 Alexander Drzezga YR 2021 UL http://jnm.snmjournals.org/content/62/7/999.abstract AB To date, 3 18F-labeled PET tracers have been approved for assessing cerebral amyloid plaque pathology in the diagnostic workup of suspected Alzheimer disease (AD). Although scanning protocols are relatively similar across tracers, U.S. Food and Drug Administration– and the European Medicines Agency–approved visual rating protocols differ among the 3 tracers. This proof-of-concept study assessed the comparability of the 3 approved visual rating protocols to classify a scan as amyloid-positive or -negative, when applied by groups of experts and nonexperts to all 3 amyloid tracers. Methods: In an international multicenter approach, both expert (n = 4) and nonexpert raters (n = 3) rated scans acquired with 18F-florbetaben, 18F-florbetapir and 18F-flutemetamol. Scans obtained with each tracer were presented for reading according to all 3 approved visual rating protocols. In a randomized order, every single scan was rated by each reader according to all 3 protocols. Raters were blinded for the amyloid tracer used and asked to rate each scan as positive or negative, giving a confidence judgment after each response. Percentage of visual reader agreement, interrater reliability, and agreement of each visual read with binary quantitative measures (fixed SUV ratio threshold for positive or negative scans) were computed. These metrics were analyzed separately for expert and nonexpert groups. Results: No significant differences in using the different approved visual rating protocols were observed across the different metrics of agreement in the group of experts. Nominal differences suggested that the 18F-florbetaben visual rating protocol achieved the highest interrater reliability and accuracy especially under low confidence conditions. For the group of nonexpert raters, significant differences between the different visual rating protocols were observed with overall moderate-to-fair accuracy and with the highest reliability for the 18F-florbetapir visual rating protocol. Conclusion: We observed high interrater agreement despite applying different visual rating protocols for all 18F-labeled amyloid tracers. This implies that the results of the visual interpretation of amyloid imaging can be well standardized and do not depend on the rating protocol in experts. Consequently, the creation of a universal visual assessment protocol for all amyloid imaging tracers appears feasible, which could benefit especially the less-experienced readers.