RT Journal Article
SR Electronic
T1 18F-6-Fluoro-l-Dopa PET/CT Imaging of Congenital Hyperinsulinism
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 51S
OP 56S
DO 10.2967/jnumed.120.246033
VO 62
IS Supplement 2
A1 Lisa J. States
A1 J. Christopher Davis
A1 Steven M. Hamel
A1 Susan A. Becker
A1 Hongming Zhuang
YR 2021
UL http://jnm.snmjournals.org/content/62/Supplement_2/51S.abstract
AB Congenital hyperinsulinism is characterized by persistent hypoglycemia due to inappropriate excess secretion of insulin resulting in hyperinsulinemic hypoglycemia. The clinical course varies from mild to severe, with a significant risk for brain damage. Imaging plays a valuable role in the care of infants and children with severe hypoglycemia unresponsive to medical therapy. 18F-6-fluoro-l-dopa PET/CT is the method of choice for the detection and localization of a focal lesion of hyperinsulinism. Surgical resection of a focal lesion can lead to a cure with limited pancreatectomy. This article reviews the role of 18F-6-fluoro-l-dopa PET/CT in the management of this vulnerable population.