RT Journal Article SR Electronic T1 18F-6-Fluoro-l-Dopa PET/CT Imaging of Congenital Hyperinsulinism JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 51S OP 56S DO 10.2967/jnumed.120.246033 VO 62 IS Supplement 2 A1 Lisa J. States A1 J. Christopher Davis A1 Steven M. Hamel A1 Susan A. Becker A1 Hongming Zhuang YR 2021 UL http://jnm.snmjournals.org/content/62/Supplement_2/51S.abstract AB Congenital hyperinsulinism is characterized by persistent hypoglycemia due to inappropriate excess secretion of insulin resulting in hyperinsulinemic hypoglycemia. The clinical course varies from mild to severe, with a significant risk for brain damage. Imaging plays a valuable role in the care of infants and children with severe hypoglycemia unresponsive to medical therapy. 18F-6-fluoro-l-dopa PET/CT is the method of choice for the detection and localization of a focal lesion of hyperinsulinism. Surgical resection of a focal lesion can lead to a cure with limited pancreatectomy. This article reviews the role of 18F-6-fluoro-l-dopa PET/CT in the management of this vulnerable population.