PT  - JOURNAL ARTICLE
AU  - Xinrui Zhang
AU  - Lisa Landgraf
AU  - Nikolaos Bailis
AU  - Michael Unger
AU  - Thies H. Jochimsen
AU  - Andreas Melzer
TI  - Image-guided High-Intensity Focused Ultrasound, A Novel Application for Interventional Nuclear Medicine?
AID  - 10.2967/jnumed.120.256230
DP  - 2021 Jun 01
TA  - Journal of Nuclear Medicine
PG  - jnumed.120.256230
4099  - http://jnm.snmjournals.org/content/early/2021/06/04/jnumed.120.256230.short
4100  - http://jnm.snmjournals.org/content/early/2021/06/04/jnumed.120.256230.full
AB  - Image-guided high-intensity focused ultrasound (HIFU) has been increasingly used in medicine over the past few decades, and several systems for such have become commercially available. HIFU has passed regulatory approval for the ablation of various solid tumors, the treatment of neurological diseases, and the palliative management of bone metastases around the world. The mechanical and thermal effects of focused ultrasound provide a possibility for histotripsy, support radiation therapy, and targeted drug delivery. The integration of imaging modalities into HIFU systems allows for precise temperature monitoring and accurate treatment planning, increasing the safety and efficiency of treatment. Preclinical and clinical results have demonstrated the potential of image-guided HIFU to reduce adverse effects and increase the quality of life postoperatively. Interventional nuclear image-guided HIFU is an attractive noninvasive option for the future.