RT Journal Article
SR Electronic
T1 What Is T+? A Gordian Knot of Tracers, Thresholds, and Topographies
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 614
OP 619
DO 10.2967/jnumed.120.245423
VO 62
IS 5
A1 Villemagne, Victor L.
A1 Lopresti, Brian J.
A1 Doré, Vincent
A1 Tudorascu, Dana
A1 Ikonomovic, Milos D.
A1 Burnham, Samantha
A1 Minhas, Davneet
A1 Pascoal, Tharick A.
A1 Mason, N. Scott
A1 Snitz, Beth
A1 Aizenstein, Howard
A1 Mathis, Chester A.
A1 Lopez, Oscar
A1 Rowe, Christopher C.
A1 Klunk, William E.
A1 Cohen, Ann D.
YR 2021
UL http://jnm.snmjournals.org/content/62/5/614.abstract
AB In this review we examine, in the context of the amyloid, tau, and neurodegeneration framework, the available evidence and potential alternatives on how to establish tau positivity (T+) for multiple tau-imaging tracers in order to reach a consensus on normal and abnormal tau imaging values that can be universally implemented in clinical research and therapeutic trials.