PT - JOURNAL ARTICLE AU - Victor L. Villemagne AU - Brian J. Lopresti AU - Vincent Doré AU - Dana Tudorascu AU - Milos D. Ikonomovic AU - Samantha Burnham AU - Davneet Minhas AU - Tharick A. Pascoal AU - N. Scott Mason AU - Beth Snitz AU - Howard Aizenstein AU - Chester A. Mathis AU - Oscar Lopez AU - Christopher C. Rowe AU - William E. Klunk AU - Ann D. Cohen TI - What Is T+? A Gordian Knot of Tracers, Thresholds, and Topographies AID - 10.2967/jnumed.120.245423 DP - 2021 May 10 TA - Journal of Nuclear Medicine PG - 614--619 VI - 62 IP - 5 4099 - http://jnm.snmjournals.org/content/62/5/614.short 4100 - http://jnm.snmjournals.org/content/62/5/614.full SO - J Nucl Med2021 May 10; 62 AB - In this review we examine, in the context of the amyloid, tau, and neurodegeneration framework, the available evidence and potential alternatives on how to establish tau positivity (T+) for multiple tau-imaging tracers in order to reach a consensus on normal and abnormal tau imaging values that can be universally implemented in clinical research and therapeutic trials.