RT Journal Article
SR Electronic
T1 High incidence of atherosclerosis in smokers demonstrated by NaF-PET/CT imaging of the major arteries
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1661
OP 1661
VO 62
IS supplement 1
A1 Chinta, Sree
A1 Bhattaru, Abhijit
A1 Rojulpote, Krishna Vamsi
A1 Zhang, Vincent
A1 Werner, Thomas
A1 Revheim, Mona-Elisabeth
A1 Hoilund-Carlsen, Poul Flemming
A1 Alavi, Abass
YR 2021
UL http://jnm.snmjournals.org/content/62/supplement_1/1661.abstract
AB 1661Objectives: In this study, we analyzed the impact of smoking on total body atherosclerosis using 18F-sodium fluoride (NaF)-positron emission tomography/computed tomography (PET/CT). We hypothesized that subjects with low risk for and subjects at-risk for cardiovascular disease (CVD), who either actively smoked or had a history of smoking, would demonstrate greater global arterial NaF uptake compared to their non-smoking controls. Methods: We compared smokers assessed to be at low risk for CVD (n = 21) to non-smokers at low risk for CVD (n = 26) and smokers assessed to be at-risk for CVD (n = 17) to non-smokers at-risk for CVD (n = 10) as assessed by the systematic coronary risk evaluation (SCORE) tool. The average of mean standardized uptake value (Avg SUVmean) was measured by mapping regions of interest of the arteries including the carotid, coronary, femoral, and popliteal arteries, as well as the aorta. Wilcoxon's rank-sum test was used to assess the differences in Avg SUVmean between smokers and their age- and sex-matched non-smoking controls. Results: Subjects who smoked and had low risk for CVD demonstrated greater Avg SUVmean in the ascending aorta (p = 0.007), aortic arch (p = 0.003), descending aorta (p ≤ 0.001), left external iliac (p = 0.002), and total vasculature (p = 0.005) compared to their non-smoking controls. Subjects who smoked and were at-risk for CVD demonstrated greater Avg SUVmean in the carotid artery (p = 0.042) and aortic arch (p = 0.029) compared to their controls. Conclusions: Global arterial NaF uptake appears to be associated with smoking status. NaF-PET/CT may be implemented as an imaging modality for evaluating the importance of smoking on micro-calcification of the arteries.View this table: @font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-536870145 1107305727 0 0 415 0;}@font-face {font-family:"Arial Unicode MS"; panose-1:2 11 6 4 2 2 2 2 2 4; mso-font-charset:128; mso-generic-font-family:swiss; mso-font-pitch:variable; mso-font-signature:-134238209 -371195905 63 0 4129279 0;}@font-face {font-family:"\@Arial Unicode MS"; panose-1:2 11 6 4 2 2 2 2 2 4; mso-font-charset:128; mso-generic-font-family:swiss; mso-font-pitch:variable; mso-font-signature:-134238209 -371195905 63 0 4129279 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Arial",sans-serif; mso-fareast-font-family:Arial; mso-ansi-language:EN;}h4 {mso-style-priority:9; mso-style-qformat:yes; mso-style-link:"Heading 4 Char"; mso-style-next:Normal; margin-top:14.0pt; margin-right:0in; margin-bottom:4.0pt; margin-left:0in; line-height:115%; mso-pagination:widow-orphan lines-together; page-break-after:avoid; mso-outline-level:4; font-size:12.0pt; font-family:"Arial",sans-serif; color:#666666; mso-ansi-language:EN; font-weight:normal;}span.Heading4Char {mso-style-name:"Heading 4 Char"; mso-style-priority:9; mso-style-unhide:no; mso-style-locked:yes; mso-style-link:"Heading 4"; mso-ansi-font-size:12.0pt; mso-bidi-font-size:12.0pt; color:#666666;}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:11.0pt; mso-ansi-font-size:11.0pt; mso-bidi-font-size:11.0pt; font-family:"Arial",sans-serif; mso-ascii-font-family:Arial; mso-fareast-font-family:Arial; mso-hansi-font-family:Arial; mso-bidi-font-family:Arial; mso-ansi-language:EN;}.MsoPapDefault {mso-style-type:export-only; line-height:115%;}div.WordSection1 {page:WordSection1;}