TY - JOUR T1 - Impact of smoking in patients with pancreatic cancer receiving a PET scan. S. Gresens, E. Braun, A.M. Voslar; Nuclear Medicine, Froedtert Hospital, Milwaukee, Wisconsin. JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 179 LP - 179 VL - 62 IS - supplement 1 AU - Sydney Gresens Y1 - 2021/05/01 UR - http://jnm.snmjournals.org/content/62/supplement_1/179.abstract N2 - 179Objectives: Smoking has been linked to numerous health problems and the development of numerous cancers. With PET imaging, the uptake of radioactive tracers F-18 FDG and Ga-68 Dotatate into cancerous regions can be seen. The objective of this study is to determine whether smoking contributes to the development of pancreatic cancer and if there’s a statistical difference in smokers and non-smokers in patients with pancreatic cancer undergoing PET scans. Methods: Patients were selected at random from an inpatient and outpatient population over a 15 month period. The patients selected underwent either a full body or head to mid-thigh PET scan with the clinical indication of pancreatic cancer. Patients were injected with either F-18 FDG or Ga-68 Dotatate. Once pancreatic cancer was confirmed by the physician’s report, whether or not the patient was a smoker was recorded. A Chi-Square Goodness of Fit test was used to determine whether the number of patients who smoked matches the expected number, and whether the results were statistically significant. Of the 59 selected patients with pancreatic cancer, 100% were expected to be smokers. Results: Out of the 59 patients selected with pancreatic cancer, 28 (47%) were non-smokers and 31 (53%) were smokers. The chi squared value was infinite with a p value of < 0.00001, which is less than the critical value of 0.05. Conclusions: There is no evidence supporting a statistical association between smoking and the development of pancreatic cancer. While the majority of selected patients were smokers, it’s important to include that smoking does not guarantee the development of pancreatic cancer. This concludes that although smoking might have been a factor in developing pancreatic cancer, there are too many outside variables not examined that contribute to pancreatic cancer to solidify a link between smoking and pancreatic cancer. ER -