TY - JOUR T1 - Is there any change in the muscle uptake pattern of FDG during or after COVID-19infection in oncological FDG PET-CT patients? JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 188 LP - 188 VL - 62 IS - supplement 1 AU - Ozge Vural Topuz AU - Aysegül Aksu AU - Burçak Yilmaz Y1 - 2021/05/01 UR - http://jnm.snmjournals.org/content/62/supplement_1/188.abstract N2 - 188Objectives: The coronavirus disease 2019 (COVID-19) is a viral pandemic caused by SARS-CoV-2, a member of the Coronavirinae subfamily. Myalgia is one of the most prevalent symptoms. The aim of this study is to investigate whether there is a change in FDG uptake of the muscles and bone marrow of patients with COVID-19 infection. Method: From august 2020 to december 2020, a total of 1260 oncological FDG PET-CT studies were performed in our center. Among 242 oncology patients whose SARS-CoV-2 PCR results were available, the data of 32 patients with concurrent SARS-CoV-2 positivity or previous disease history and the data of 36 covid negative patients were analyzed retrospectively. Patients tested positive COVİD-19 were divided into 3 groups (14 days, 1 month and 3 months) according to the time interval between the active period of the disease and FDG PET-CT imaging. FDG uptake in paraspinal, deltoid, psoas, gluteal muscles and also sacrum of each patient were measured separately, the SUVmax and the SUVmean values were recorded. The FDG uptake in paraspinal,deltoid, psoas, gluteal muscles and sacrum of the covid-negative patient group were measured and recorded the same way as the study group. Other imaging findings that may be related to COVID-19 were also noted. Mann-Whitney U-test was used to assess differences in metabolic parameters between the groups. Statistical significance was defined as p<0.05. Patients were asked about their muscle pain in the active phase of the COVID-19 and the pain rating scale used to rate the intensity of the pain. Results: Sixty eight patients with a mean age of 56±15 (5-80) years were included in the study. There were 32 females and 36 males. Median SUVmean and SUVmax values ​​in the psoas muscle of 15 patients whose time period between the SARS-CoV-2 PCR test positivity and FDG PET-CT imaging was less than 15 days were significantly higher than the median SUVmean and SUVmax values in the psoas muscle of covid-negative patient group (p: 0.04 and 0.016, respectively). Moreover, the bone marrow SUVmean and SUVmax values ​​obtained from the sacrum were also found to be higher in this group (p: 0.036 and 0.016, respectively).In the patient group whose PET-CT imaging was performed 1 month after SARS-CoV-2 PCR test positivity, the SUVmax values ​​obtained from the psoas muscle were significantly higher than the SUVmax values ​​in the covid negative group (p: 0.043). There was no significant difference between the SUV parameters obtained from the muscle groups and bone marrow of patients who were tested for SARS-CoV-2 positivity or with a known history of COVID-19, and the SUV parameters obtained from covid-negative patients. Conclusion: Since the disease is new, there are many questions about the course of the disease and its early and late findings. Despite being a small sample, in our study, it was shown that some COVID-19 patients in the early stage of the disease may show increased FDG uptake in some muscle groups and also in bone marrow. Keywords: Covid 19, FDG PET-CT, Muscle ER -